Association between Diabetes and Levels of Micronutrients in Qatar—A Case–Control Study
Author | Soliman, Nada |
Author | Almishal, Ruba |
Author | Elsayed, Basant |
Author | Ahmed, Ayaaz |
Author | Al-Amri, Sara |
Author | Al-Kuwari, Aisha |
Author | Al-Muhannadi, Shaikha |
Author | Nadeer, Muhammed |
Author | Chivese, Tawanda |
Available date | 2024-03-13T05:14:56Z |
Publication Date | 2023 |
Publication Name | Biomedicines |
Resource | Scopus |
ISSN | 22279059 |
Abstract | Objective: The objectives of this study were to investigate associations between micronutrient levels and diabetes and to explore the association in individuals with controlled and uncontrolled diabetes. Methods: A case–control study, matched on age and gender, was performed on participants with (cases) and without diabetes (controls), who were Qatari or long-term residents (≥15 years of residence). Participants with diabetes were divided into those with controlled and uncontrolled diabetes using an HbA1c cutoff of 7%. Levels of micronutrients were measured from serum and categorized into normal and abnormal levels. Results: A total of 1118 participants (374 cases and 744 controls) were included with a mean age of 41.7 years (SD 9.9), of whom 53.9% were female. Of those with diabetes, 229 had controlled diabetes and 145 had uncontrolled diabetes. Compared to those without diabetes, participants with diabetes had significantly lower mean magnesium (0.80 mmol/L (SD 0.07) vs. 0.84 mmol/L (SD 0.06), respectively, p < 0.001). Lower magnesium and iron were observed in participants with uncontrolled compared to participants with controlled diabetes. After multivariable logistic regression, diabetes was associated with hypomagnesemia (OR 3.2, 95% CI 3.4–213.9) and low iron (OR 1.49, 95% CI 1.03–2.15). Uncontrolled diabetes showed stronger odds of association with hypomagnesemia (OR 5.57, 95% CI 3.65–8.52). Conclusion: In an affluent setting in the MENA region, diabetes was associated with low magnesium and low iron, and this association was stronger in individuals with uncontrolled diabetes. |
Sponsor | The publication of this article was funded by the Qatar National Library. |
Language | en |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
Subject | diabetes control diabetes mellitus macroelements magnesium microelements Qatar Biobank (QBB) vitamins |
Type | Article |
Issue Number | 11 |
Volume Number | 11 |
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