تصفح Laboratory Animal Research Center (Research) حسب النوع "Article Review"

السجلات المعروضة 1 -- 20 من 44

    • Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies 

      Prabhu, Kirti S.; Jessy, Serah; Kuttikrishnan, Shilpa; Mujeeb, Farina; Mariyam, Zahwa; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)
      The growing global burden of malignant tumors with increasing incidence and mortality rates underscores the urgent need for more effective and less toxic therapeutic options. Herbal compounds are being increasingly studied ...

    • Applications of polydopaminic nanomaterials in mucosal drug delivery 

      Takwa, Bedhiafi; Idoudi, Sourour; Alhams, Areej Ali; Fernandes, Queenie; Iqbal, Heba; ... more authors ( Elsevier , 2023 , Article Review)
      Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ...

    • Association of genes with phenotype in autism spectrum disorder. 

      Nisar, Sabah; Hashem, Sheema; Bhat, Ajaz A; Syed, Najeeb; Yadav, Santosh; ... more authors ( Impact Journals , 2019 , Article Review)
      Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that is characterized by impairments in social interaction and speech development and is accompanied by stereotypical behaviors such as ...

    • Beyond genetics: Exploring the role of epigenetic alterations in breast cancer 

      Prabhu, Kirti S.; Sadida, Hana Q.; Kuttikrishnan, Shilpa; Junejo, Kulsoom; Bhat, Ajaz A.; ... more authors ( Elsevier , 2024 , Article Review)
      Breast cancer remains a major global health challenge. Its rising incidence is attributed to factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug resistance, all contributing to less-than-ideal ...

    • Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury 

      Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2019 , Article Review)
      Cadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing ...

    • Cadmium: An Emerging Role in Adipose Tissue Dysfunction 

      Attia, Sarra Mohammed; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Springer , 2021 , Article Review)
      Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and ...

    • Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance 

      Bhat, Gh Rasool; Sethi, Itty; Sadida, Hana Q.; Rah, Bilal; Mir, Rashid; ... more authors ( Springer , 2024 , Article Review)
      Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to ...

    • Cardiovascular challenges in the era of antiretroviral therapy for AIDS/ HIV: A comprehensive review of research advancements, pathophysiological insights, and future directions 

      Suleman, Muhammad; Khan, Shahid Ullah; Hussain, Talib; Khan, Munir Ullah; Shamsul Hassan, Syed; ... more authors ( Elsevier , 2024 , Article Review)
      Cardiovascular disease, particularly coronary heart disease, is becoming more common among those living with HIV. Individuals with HIV face an increased susceptibility to myocardial infarction, also known as a heart attack, ...

    • Cardiovascular diseases crossroads: cGAS-STING signaling and disease progression 

      Khan, Muhammad Shehzad; Khan, Shahid Ullah; Khan, Safir Ullah; Suleman, Muhammad; Shan Ahmad, Rafi u; ... more authors ( Elsevier , 2024 , Article Review)
      It is now widely accepted that inflammation is critical in cardiovascular diseases (CVD). Here, studies are being conducted on how cyclic GMP-AMP synthase (cGAS), a component of innate immunity's DNA-sensing machinery, ...

    • Chemokine-cytokine networks in the head and neck tumor microenvironment 

      Nisar, Sabah; Yousuf, Parvaiz; Masoodi, Tariq; Wani, Nissar A.; Hashem, Sheema; ... more authors ( MDPI , 2021 , Article Review)
      Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ...

    • Chronic inflammation and cancer; the two sides of a coin 

      Fernandes, Queenie; Inchakalody, Varghese Philipose; Bedhiafi, Takwa; Mestiri, Sarra; Taib, Nassiba; ... more authors ( Elsevier , 2024 , Article Review)
      The correlation between chronic inflammation and cancer was initially identified in the 19th century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors, and adhesion molecules, which regulate ...

    • Claudin-1, A Double-Edged Sword in Cancer. 

      Bhat, Ajaz A; Syed, Najeeb; Therachiyil, Lubna; Nisar, Sabah; Hashem, Sheema; ... more authors ( MDPI , 2020 , Article Review)
      Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated ...

    • Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy 

      Bhat, Ajaz A.; Nisar, Sabah; Singh, Mayank; Ashraf, Bazella; Masoodi, Tariq; ... more authors ( Wiley , 2022 , Article Review)
      Colorectal cancer (CRC) is a predominant life-threatening cancer, with liver and peritoneal metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor, nurtures a local inflammatory environment ...

    • Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy 

      Bhat, A.A.; Bhat, Ajaz A.; Nisar, Sabah; Maacha, Selma; Carneiro-Lobo, Tatiana Correa; ... more authors ( BMC , 2021 , Article Review)
      Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account ...

    • Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications. 

      Sher, Gulab; Salman, Nadia Aziz; Khan, Abdul Q; Prabhu, Kirti S; Raza, Afsheen; ... more authors ( Elsevier , 2020 , Article Review)
      The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ...

    • Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions 

      Alsayed, Reem Khaled M.E.; Sheikhan, Khalid Sultan A.M.; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; ... more authors ( Elsevier , 2023 , Article Review)
      Cancer ‘stemness’ is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the ...

    • Exploring Dysregulated Signaling Pathways in Cancer. 

      Nisar, Sabah; Hashem, Sheema; Yadav, Santosh K; Muralitharan, Sankavi; Therachiyil, Lubna; ... more authors ( Bentham Science Publishers , 2020 , Article Review)
      Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular ...

    • Fatty acid synthase: A key driver of ovarian cancer metastasis and a promising therapeutic target 

      Ahmad, Nuha; Moton, Safwan; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Masoodi, Tariq; ... more authors ( Elsevier , 2024 , Article Review)
      Fatty acid synthase (FASN) is a critical enzyme essential for the production of fats in the body. The abnormal expression of FASN is associated with different types of malignancies, including ovarian cancer. FASN plays a ...

    • Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients 

      Isaifan, Dina; Crovella, Sergio; Soubra, Lama; Al-Nesf, Maryam; Steinhoff, Martin ( MDPI , 2023 , Article Review)
      Atopic dermatitis (AD) is the most common chronic relapsing neuroinflammatory skin disease that is characterized by a complex and multifactorial pathophysiology. It reflects a profound interplay between genetic and ...

    • Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder. 

      Nisar, Sabah; Bhat, Ajaz A; Hashem, Sheema; Syed, Najeeb; Yadav, Santosh K; ... more authors ( MDPI , 2020 , Article Review)
      Post-traumatic stress disorder (PTSD) is a highly disabling condition, increasingly recognized as both a disorder of mental health and social burden, but also as an anxiety disorder characterized by fear, stress, and ...