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AuthorAlshwyeh, Hussah Abdullah
AuthorAl-Sheikh, Warqaa Muhammed Shariff
AuthorRasedee, Abdullah
AuthorAlnasser, Sulaiman Mohammed
AuthorAl-Qubaisi, Mothanna Sadiq
AuthorIbrahim, Wisam Nabeel
Available date2024-03-14T08:03:07Z
Publication Date2024-01-01
Publication NameMolecular and Cellular Oncology
Identifierhttp://dx.doi.org/10.1080/23723556.2023.2299046
CitationAlshwyeh, H. A., Al-Sheikh, W. M. S., Rasedee, A., Alnasser, S. M., Al-Qubaisi, M. S., & Ibrahim, W. N. (2024). Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells. Molecular & Cellular Oncology, 11(1), 2299046.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85181715386&origin=inward
URIhttp://hdl.handle.net/10576/53061
AbstractIn this study, we investigated the effects of an ethanolic extract of Mangifera indica L. kernel on the viability and proliferation of human lung cancer cells. We utilized MTT and BrdU cell proliferation assays, morphological assessments, cell cycle analyses, and apoptosis assays to investigate the extract’s effects on lung cancer (A549 and NCI-H292) and normal lung (MRC-5) cells. The extract demonstrated a toxicity toward cancer cells compared to normal cells with dose-dependent anti-proliferative effect on lung cancer cells. The extract also caused differential effects on the cell cycle, inducing G0/G1 arrest and increasing the Sub-G1 population in both lung cancer and normal lung cells. Notably, the extract induced loss of membrane integrity, shrinkage, membrane blebbing, and apoptosis in lung cancer cells, while normal cells exhibited only early apoptosis. Furthermore, the extract exhibited higher toxicity towards NCI-H292 cells, followed by A549 and normal MRC-5 cells in decreasing order of potency. Our results suggest that the ethanolic extract of M. indica L. kernel has significant potential as a novel therapeutic agent for treating lung cancer cells, given its ability to induce apoptosis in cancer cell lines while causing minimal harm to normal cells.
Languageen
PublisherTaylor and Francis Ltd.
SubjectA549 cells
apoptosis
cell cycle arrest
Mangifera indica L
NCI-H292 cells
TitleMangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
TypeArticle
Issue Number1
Volume Number11
dc.accessType Abstract Only


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