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المؤلفMir, Fayaz Ahmad
المؤلفAbdesselem, Houari B.
المؤلفCyprian, Farhan
المؤلفIskandarani, Ahmad
المؤلفDoudin, Asmma
المؤلفSamra, Tareq A.
المؤلفAlkasem, Meis
المؤلفAbdalhakam, Ibrahem
المؤلفTaheri, Shahrad
المؤلفAbou-Samra, Abdul Badi
تاريخ الإتاحة2024-03-14T08:34:01Z
تاريخ النشر2023-12-13
اسم المنشورScientific Reports
المعرّفhttp://dx.doi.org/10.1038/s41598-023-49643-8
الاقتباسMir, F. A., Abdesselem, H. B., Cyprian, F., Iskandarani, A., Doudin, A., Samra, T. A., ... & Abou-Samra, A. B. (2023). Inflammatory protein signatures in individuals with obesity and metabolic syndrome. Scientific Reports, 13(1), 22185.
الرقم المعياري الدولي للكتاب2045-2322
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85179743116&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/53063
الملخصThere is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased risk of cardiovascular disease and type 2 diabetes. The mechanisms contributing to this metabolic heterogeneity are not fully understood. To address this question, plasma samples from 48 individuals with BMI ≥ 35 kg/m2 were examined (27 with and 21 without metabolic syndrome). Fasting plasma samples were subjected to Olink proteomics analysis for 184 cardiometabolic and inflammation-enriched proteins. Data analysis showed a clear differentiation between the two groups with distinct plasma protein expression profiles. Twenty-four proteins were differentially expressed (DEPs) between the two groups. Pathways related to immune cell migration, leukocyte chemotaxis, chemokine signaling, mucosal inflammatory response, tissue repair and remodeling were enriched in the group with metabolic syndrome. Functional analysis of DEPs revealed upregulation of 15 immunological pathways. The study identifies some of the pathways that are altered and reflect metabolic health in individuals with obesity. This provides valuable insights into some of the underlying mechanisms and can lead to identification of therapeutic targets to improve metabolic health in individuals with obesity.
راعي المشروعResearch conducted on Qatar cohort was funded by Qatar Metabolic Institute (QMI), Hamad Medical Corporation, Doha Qatar. Qatar National Library funded the publication of this article.
اللغةen
الناشرSpringer Nature
الموضوعcardiovascular disease
insulin resistance
العنوانInflammatory protein signatures in individuals with obesity and metabolic syndrome
النوعArticle
رقم العدد1
رقم المجلد13
dc.accessType Open Access


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