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AuthorMcGrath, John J
AuthorAl-Hamzawi, Ali
AuthorAlonso, Jordi
AuthorAltwaijri, Yasmin
AuthorAndrade, Laura H
AuthorBromet, Evelyn J
AuthorBruffaerts, Ronny
Authorde Almeida, José Miguel Caldas
AuthorChardoul, Stephanie
AuthorChiu, Wai Tat
AuthorDegenhardt, Louisa
AuthorDemler, Olga V
AuthorFerry, Finola
AuthorGureje, Oye
AuthorHaro, Josep Maria
AuthorKaram, Elie G
AuthorKaram, Georges
AuthorKhaled, Salma M
AuthorKovess-Masfety, Viviane
AuthorMagno, Marta
AuthorMedina-Mora, Maria Elena
AuthorMoskalewicz, Jacek
AuthorNavarro-Mateu, Fernando
AuthorNishi, Daisuke
AuthorPlana-Ripoll, Oleguer
AuthorPosada-Villa, José
AuthorRapsey, Charlene
AuthorSampson, Nancy A
AuthorStagnaro, Juan Carlos
AuthorStein, Dan J
Authorten Have, Margreet
AuthorTorres, Yolanda
AuthorVladescu, Cristian
AuthorWoodruff, Peter W
AuthorZarkov, Zahari
AuthorKessler, Ronald C
AuthorAguilar-Gaxiola, Sergio
AuthorAl-Hamzawi, Ali
AuthorAlonso, Jordi
AuthorAltwaijri, Yasmin A.
AuthorAndrade, Laura Helena
AuthorAtwoli, Lukoye
AuthorBenjet, Corina
AuthorBromet, Evelyn J.
AuthorBruffaerts, Ronny
AuthorBunting, Brendan
AuthorCaldas-de-Almeida, José Miguel
AuthorCardoso, Graça
AuthorChardoul, Stephanie
AuthorCía, Alfredo H.
AuthorDegenhardt, Louisa
AuthorDe Girolamo, Giovanni
AuthorGureje, Oye
AuthorHaro, Josep Maria
AuthorHarris, Meredith G.
AuthorHinkov, Hristo
AuthorHu, Chi-yi
AuthorDe Jonge, Peter
AuthorKaram, Aimee N.
AuthorKaram, Elie G.
AuthorKaram, Georges
AuthorKazdin, Alan E.
AuthorKawakami, Norito
AuthorKessler, Ronald C.
AuthorKiejna, Andrzej
AuthorKovess-Masfety, Viviane
AuthorMcGrath, John J.
AuthorMedina-Mora, Maria Elena
AuthorMoskalewicz, Jacek
AuthorNavarro-Mateu, Fernando
AuthorNishi, Daisuke
AuthorPiazza, Marina
AuthorPosada-Villa,José
AuthorScott, Kate M.
AuthorStagnaro, Juan Carlos
AuthorStein, Dan J.
AuthorTen Have, Margreet
AuthorTorres, Yolanda
AuthorViana, Maria Carmen
AuthorVigo, Daniel V.
AuthorVladescu, Cristian
AuthorWilliams, David R.
AuthorWoodruff, Peter
AuthorWojtyniak, Bogdan
AuthorXavier, Miguel
AuthorZaslavsky, Alan M.
Available date2024-04-02T06:04:51Z
Publication Date2023
Publication NameThe Lancet Psychiatry
ResourceScopus
ISSN22150366
URIhttp://dx.doi.org/10.1016/S2215-0366(23)00193-1
URIhttp://hdl.handle.net/10576/53808
AbstractBackground Information on the frequency and timing of mental disorder onsets across the lifespan is of fundamental importance for public health planning. Broad, cross-national estimates of this information from coordinated general population surveys were last updated in 2007. We aimed to provide updated and improved estimates of age-of-onset distributions, lifetime prevalence, and morbid risk. Methods In this cross-national analysis, we analysed data from respondents aged 18 years or older to the World Mental Health surveys, a coordinated series of cross-sectional, face-to-face community epidemiological surveys administered between 2001 and 2022. In the surveys, the WHO Composite International Diagnostic Interview, a fully structured psychiatric diagnostic interview, was used to assess age of onset, lifetime prevalence, and morbid risk of 13 DSM-IV mental disorders until age 75 years across surveys by sex. We did not assess ethnicity. The surveys were geographically clustered and weighted to adjust for selection probability, and standard errors of incidence rates and cumulative incidence curves were calculated using the jackknife repeated replications simulation method, taking weighting and geographical clustering of data into account. Findings We included 156 331 respondents from 32 surveys in 29 countries, including 12 low-income and middle-income countries and 17 high-income countries, and including 85 308 (54·5%) female respondents and 71 023 (45·4%) male respondents. The lifetime prevalence of any mental disorder was 28·6% (95% CI 27·9–29·2) for male respondents and 29·8% (29·2–30·3) for female respondents. Morbid risk of any mental disorder by age 75 years was 46·4% (44·9–47·8) for male respondents and 53·1% (51·9–54·3) for female respondents. Conditional probabilities of first onset peaked at approximately age 15 years, with a median age of onset of 19 years (IQR 14–32) for male respondents and 20 years (12–36) for female respondents. The two most prevalent disorders were alcohol use disorder and major depressive disorder for male respondents and major depressive disorder and specific phobia for female respondents. Interpretation By age 75 years, approximately half the population can expect to develop one or more of the 13 mental disorders considered in this Article. These disorders typically first emerge in childhood, adolescence, or young adulthood. Services should have the capacity to detect and treat common mental disorders promptly and to optimise care that suits people at these crucial parts of the life course.
SponsorAccess to the cross-national World Mental Health (WMH) data is governed by the organisations responsible for funding and survey data collection in each country. These organisations made data available to the WMH survey consortium through restricted data sharing agreements that do not allow data to be released to third parties. US data are available for secondary analysis via the Inter-University Consortium for Political and Social Research ( http://www.icpsr.umich.edu/icpsrweb/ICPSR/series/00527 ). A complete list of all within-country and cross-national WMH publications is available ( http://www.hcp.med.harvard.edu/wmh/ ). No additional data or materials will be made available.
Languageen
PublisherElsevier
SubjectAge of onset
cumulative risk
mental disorders
public health planning
alcohol use disorder
major depressive disorder
male respondents
major depressive disorder
specific phobia
female respondents
TitleAge of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries
TypeArticle
Pagination668-681
Issue Number9
Volume Number10
dc.accessType Abstract Only


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