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المؤلفYalcin, Huseyin C.
المؤلفAmindari, Armin
المؤلفButcher, Jonathan T.
المؤلفAlthani, Asma
المؤلفYacoub, Magdi
تاريخ الإتاحة2017-03-20T10:06:52Z
تاريخ النشر2017-03-01
اسم المنشورDevelopmental Dynamics
المعرّفhttp://dx.doi.org/10.1002/dvdy.24497
الاقتباسHuseyin C. Yalcin, Armin Amindari, Jonathan T. Butcher, Asma Althani and Magdi Yacoub "Heart Function and Hemodynamics Analysis for Zebrafish Embryos" Developmental Dynamics (2017)
الرقم المعياري الدولي للكتاب1058-8388
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5387
الملخصThe zebrafish has emerged to become a powerful vertebrate animal model for cardiovascular research in recent years. Its advantages include easy genetic manipulation, transparency, small size, low cost, and the ability to survive without active circulation at early stages of development. Sequencing the whole genome and identifying orthologue genes with human genome enabled to induce clinically relevant cardiovascular defects via genetic approaches. Heart function and disturbed hemodynamics need to be assessed in a reliable manner for these disease models in order to reveal mechanobiology of induced defects. This effort requires precise determination of blood flow patterns as well as hemodynamic stress (i.e. wall shear stress and pressure) levels within the developing heart. While traditional approach involves time-lapse brightfield microscopy to track cell and tissue movements, in more recent studies fast light sheet fluorescent microscopes are utilized for that purpose. Integration of more complicated techniques like particle image velocimetry and computational fluid dynamics modeling for hemodynamic analysis holds a great promise to the advancement of the zebrafish studies. Here, we discuss the latest developments in heart function and hemodynamic analysis for zebrafish embryos and conclude with our future perspective on dynamic analysis of zebrafish cardiovascular system.
راعي المشروعThis research was supported by Qatar University internal grants (QUST-BRC-SPR\2017-1 and QUUG-BRC-2017-3 to HCY).
اللغةen
الناشرWiley
الموضوعzebrafish embryo
hemodynamics
blood flow
heart development
shear stress
pressure
mechanobiology
time lapse microscopy
light sheet fluorescent microscopy
particle image velocimetry
computational fluid dynamics
العنوانHeart Function and Hemodynamics Analysis for Zebrafish Embryos
النوعArticle
ESSN1097-0177
dc.accessType Open Access


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