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المؤلفYagi, Sakina
المؤلفNilofar, Nilofar
المؤلفUba, Abdullahi Ibrahim
المؤلفCaprioli, Giovanni
المؤلفMustafa, Ahmed M.
المؤلفAngeloni, Simone
المؤلفKoyuncu, Ismail
المؤلفSeker, Fatma
المؤلفPolat, Rıdvan
المؤلفSupti, Sumaiya Jahan
المؤلفTasnim, Faria
المؤلفAl Dhaheri, Yusra
المؤلفZengin, Gokhan
المؤلفEid, Ali H.
تاريخ الإتاحة2024-04-24T09:53:24Z
تاريخ النشر2024
اسم المنشورFrontiers in Pharmacology
المصدرScopus
الرقم المعياري الدولي للكتاب16639812
معرّف المصادر الموحدhttp://dx.doi.org/10.3389/fphar.2024.1333865
معرّف المصادر الموحدhttp://hdl.handle.net/10576/54207
الملخصThe present study was designed to evaluate the chemical composition, antioxidant, enzyme inhibition and cytotoxic properties of different extracts from aerial parts of V. diversifolium (family Scrophulariaceae), a plant that is native to Lebanon, Syria and Turkey. Six extracts, namely, hexane, dichloromethane (DCM), ethyl acetate (EtOAc), ethanol (EtOH), 70% EtOH, and water (aqueous) were prepared by maceration. The EtOH extract was predominated by the presence of rutin (4280.20 μg g−1) and p-coumaric acid (3044.01 μg g−1) while the highest accumulation of kaempferol-3-glucoside (1537.38 μg g−1), caffeic acid (130.13 μg g−1) and 4-hydroxy benzoic acid (465.93 μg g−1) was recorded in the 70% EtOH, aqueous, and EtOAc extracts, respectively. The EtOH (46.86 mg TE/g) and 70% EtOH (46.33 mg TE/g) extracts displayed the highest DPPH radical scavenging result. Both these extracts, along with the aqueous one, exerted the highest ABTS radical scavenging result (73.03–73.56 mg TE/g). The EtOH and 70% EtOH extracts revealed the most potent anti-AChE (2.66 and 2.64 mg GALAE/g) and anti-glucosidase (1.07 and 1.09 mmol ACAE/g) activities. The aqueous extract was the most efficacious in inhibiting the proliferation of prostate cancer (DU-145) cells with an IC50 of 8.71 μg/mL and a Selectivity Index of 3.7. In conclusion, this study appraised the use of V. diversifolium aerial parts as a potential therapeutic source for future development of phytopharmaceuticals that target specific oxidative stress-linked diseases including diabetes, cancer, cardiovascular disease, and Alzheimer’s disease among others.
راعي المشروعThe author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
اللغةen
الناشرFrontiers Media SA
الموضوعcancer
cardiovascular disease
Herbal medicine
oxidative stress
reactive oxgen species (ROS)
العنوانElucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts
النوعArticle
رقم المجلد15
dc.accessType Open Access


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