Elucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts
المؤلف | Yagi, Sakina |
المؤلف | Nilofar, Nilofar |
المؤلف | Uba, Abdullahi Ibrahim |
المؤلف | Caprioli, Giovanni |
المؤلف | Mustafa, Ahmed M. |
المؤلف | Angeloni, Simone |
المؤلف | Koyuncu, Ismail |
المؤلف | Seker, Fatma |
المؤلف | Polat, Rıdvan |
المؤلف | Supti, Sumaiya Jahan |
المؤلف | Tasnim, Faria |
المؤلف | Al Dhaheri, Yusra |
المؤلف | Zengin, Gokhan |
المؤلف | Eid, Ali H. |
تاريخ الإتاحة | 2024-04-24T09:53:24Z |
تاريخ النشر | 2024 |
اسم المنشور | Frontiers in Pharmacology |
المصدر | Scopus |
الرقم المعياري الدولي للكتاب | 16639812 |
الملخص | The present study was designed to evaluate the chemical composition, antioxidant, enzyme inhibition and cytotoxic properties of different extracts from aerial parts of V. diversifolium (family Scrophulariaceae), a plant that is native to Lebanon, Syria and Turkey. Six extracts, namely, hexane, dichloromethane (DCM), ethyl acetate (EtOAc), ethanol (EtOH), 70% EtOH, and water (aqueous) were prepared by maceration. The EtOH extract was predominated by the presence of rutin (4280.20 μg g−1) and p-coumaric acid (3044.01 μg g−1) while the highest accumulation of kaempferol-3-glucoside (1537.38 μg g−1), caffeic acid (130.13 μg g−1) and 4-hydroxy benzoic acid (465.93 μg g−1) was recorded in the 70% EtOH, aqueous, and EtOAc extracts, respectively. The EtOH (46.86 mg TE/g) and 70% EtOH (46.33 mg TE/g) extracts displayed the highest DPPH radical scavenging result. Both these extracts, along with the aqueous one, exerted the highest ABTS radical scavenging result (73.03–73.56 mg TE/g). The EtOH and 70% EtOH extracts revealed the most potent anti-AChE (2.66 and 2.64 mg GALAE/g) and anti-glucosidase (1.07 and 1.09 mmol ACAE/g) activities. The aqueous extract was the most efficacious in inhibiting the proliferation of prostate cancer (DU-145) cells with an IC50 of 8.71 μg/mL and a Selectivity Index of 3.7. In conclusion, this study appraised the use of V. diversifolium aerial parts as a potential therapeutic source for future development of phytopharmaceuticals that target specific oxidative stress-linked diseases including diabetes, cancer, cardiovascular disease, and Alzheimer’s disease among others. |
راعي المشروع | The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article. |
اللغة | en |
الناشر | Frontiers Media SA |
الموضوع | cancer cardiovascular disease Herbal medicine oxidative stress reactive oxgen species (ROS) |
النوع | Article |
رقم المجلد | 15 |
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