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AuthorYagi, Sakina
AuthorNilofar, Nilofar
AuthorUba, Abdullahi Ibrahim
AuthorCaprioli, Giovanni
AuthorMustafa, Ahmed M.
AuthorAngeloni, Simone
AuthorKoyuncu, Ismail
AuthorSeker, Fatma
AuthorPolat, Rıdvan
AuthorSupti, Sumaiya Jahan
AuthorTasnim, Faria
AuthorAl Dhaheri, Yusra
AuthorZengin, Gokhan
AuthorEid, Ali H.
Available date2024-04-24T09:53:24Z
Publication Date2024
Publication NameFrontiers in Pharmacology
ResourceScopus
ISSN16639812
URIhttp://dx.doi.org/10.3389/fphar.2024.1333865
URIhttp://hdl.handle.net/10576/54207
AbstractThe present study was designed to evaluate the chemical composition, antioxidant, enzyme inhibition and cytotoxic properties of different extracts from aerial parts of V. diversifolium (family Scrophulariaceae), a plant that is native to Lebanon, Syria and Turkey. Six extracts, namely, hexane, dichloromethane (DCM), ethyl acetate (EtOAc), ethanol (EtOH), 70% EtOH, and water (aqueous) were prepared by maceration. The EtOH extract was predominated by the presence of rutin (4280.20 μg g−1) and p-coumaric acid (3044.01 μg g−1) while the highest accumulation of kaempferol-3-glucoside (1537.38 μg g−1), caffeic acid (130.13 μg g−1) and 4-hydroxy benzoic acid (465.93 μg g−1) was recorded in the 70% EtOH, aqueous, and EtOAc extracts, respectively. The EtOH (46.86 mg TE/g) and 70% EtOH (46.33 mg TE/g) extracts displayed the highest DPPH radical scavenging result. Both these extracts, along with the aqueous one, exerted the highest ABTS radical scavenging result (73.03–73.56 mg TE/g). The EtOH and 70% EtOH extracts revealed the most potent anti-AChE (2.66 and 2.64 mg GALAE/g) and anti-glucosidase (1.07 and 1.09 mmol ACAE/g) activities. The aqueous extract was the most efficacious in inhibiting the proliferation of prostate cancer (DU-145) cells with an IC50 of 8.71 μg/mL and a Selectivity Index of 3.7. In conclusion, this study appraised the use of V. diversifolium aerial parts as a potential therapeutic source for future development of phytopharmaceuticals that target specific oxidative stress-linked diseases including diabetes, cancer, cardiovascular disease, and Alzheimer’s disease among others.
SponsorThe author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Languageen
PublisherFrontiers Media SA
Subjectcancer
cardiovascular disease
Herbal medicine
oxidative stress
reactive oxgen species (ROS)
TitleElucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts
TypeArticle
Volume Number15
dc.accessType Open Access


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