Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
المؤلف | Ibisevic, Nermina |
المؤلف | Tomic, Kresimir |
المؤلف | Humackic, Alen |
المؤلف | Guzin, Zlatko |
المؤلف | Lukic, Blanka |
المؤلف | Vranic, Semir |
تاريخ الإتاحة | 2024-04-25T06:20:12Z |
تاريخ النشر | 2024 |
اسم المنشور | Croatian Medical Journal |
المصدر | Scopus |
الرقم المعياري الدولي للكتاب | 3539504 |
الملخص | Uterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavo-rable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpa-ble left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neo-plasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, re-vealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 x 130 mm), initially diagnosed as symplastic leiomyoma, was morpho-logically identical to the breast lesion. Additional diagnostic work-up revealed multiple liver and pulmonary metastases with a suspected metastatic sclerotic lesion in the L3 projection. The patient was subsequently treated with chemotherapy protocol for metastatic uLMS. The latest fol-low-up in September 2023 confirmed stable disease. This case highlights the importance of considering unusual metastatic patterns when evaluating breast masses, par-ticularly in patients with a history of non-specific uterine conditions. Comprehensive diagnostic work-up, including imaging and histopathologic examinations, is crucial for an accurate diagnosis of uLMS and appropriate treatment se-lection. Further studies are needed to better understand the underlying mechanisms and optimal management strategies for metastatic uLMS. |
اللغة | en |
الناشر | Medicinska Naklada Zagreb |
الموضوع | antineoplastic agent cytokeratin 5 cytokeratin 6 desmin (protein) filgrastim leukocyte antigen myosin antineoplastic agent abdominal hysterectomy abdominal pain adult Article breast disease breast imaging reporting and data system breast lump breast surgery breast tumor cancer chemotherapy cancer grading case report clinical article clinical protocol computer assisted tomography female follow up histopathology human human cell human tissue image analysis immunohistochemistry liver metastasis lung metastasis mammography medical history metastasis potential middle aged multidetector computed tomography needle biopsy salpingooophorectomy segmentectomy spindle cell treatment outcome tumor volume uterine leiomyosarcoma uterus myoma diagnostic imaging leiomyoma leiomyosarcoma liver lung tumor Antineoplastic Combined Chemotherapy Protocols Female Humans Leiomyoma Leiomyosarcoma Liver Lung Neoplasms Middle Aged |
النوع | Article |
الصفحات | 51-58 |
رقم العدد | 1 |
رقم المجلد | 65 |
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