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المؤلفIbisevic, Nermina
المؤلفTomic, Kresimir
المؤلفHumackic, Alen
المؤلفGuzin, Zlatko
المؤلفLukic, Blanka
المؤلفVranic, Semir
تاريخ الإتاحة2024-04-25T06:20:12Z
تاريخ النشر2024
اسم المنشورCroatian Medical Journal
المصدرScopus
الرقم المعياري الدولي للكتاب3539504
معرّف المصادر الموحدhttp://dx.doi.org/10.3325/cmj.2024.65.51
معرّف المصادر الموحدhttp://hdl.handle.net/10576/54235
الملخصUterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavo-rable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, palpa-ble left breast mass measuring 20 mm. A core biopsy of the breast mass demonstrated a cellular spindle cell neo-plasm (a potentially malignant smooth muscle neoplasm; B4). A wide local breast-mass excision was performed, re-vealing grade-2 leiomyosarcoma. A re-review of the uterine fibroids revealed that the largest one (200 x 130 mm), initially diagnosed as symplastic leiomyoma, was morpho-logically identical to the breast lesion. Additional diagnostic work-up revealed multiple liver and pulmonary metastases with a suspected metastatic sclerotic lesion in the L3 projection. The patient was subsequently treated with chemotherapy protocol for metastatic uLMS. The latest fol-low-up in September 2023 confirmed stable disease. This case highlights the importance of considering unusual metastatic patterns when evaluating breast masses, par-ticularly in patients with a history of non-specific uterine conditions. Comprehensive diagnostic work-up, including imaging and histopathologic examinations, is crucial for an accurate diagnosis of uLMS and appropriate treatment se-lection. Further studies are needed to better understand the underlying mechanisms and optimal management strategies for metastatic uLMS.
اللغةen
الناشرMedicinska Naklada Zagreb
الموضوعantineoplastic agent
cytokeratin 5
cytokeratin 6
desmin (protein)
filgrastim
leukocyte antigen
myosin
antineoplastic agent
abdominal hysterectomy
abdominal pain
adult
Article
breast disease
breast imaging reporting and data system
breast lump
breast surgery
breast tumor
cancer chemotherapy
cancer grading
case report
clinical article
clinical protocol
computer assisted tomography
female
follow up
histopathology
human
human cell
human tissue
image analysis
immunohistochemistry
liver metastasis
lung metastasis
mammography
medical history
metastasis potential
middle aged
multidetector computed tomography
needle biopsy
salpingooophorectomy
segmentectomy
spindle cell
treatment outcome
tumor volume
uterine leiomyosarcoma
uterus myoma
diagnostic imaging
leiomyoma
leiomyosarcoma
liver
lung tumor
Antineoplastic Combined Chemotherapy Protocols
Female
Humans
Leiomyoma
Leiomyosarcoma
Liver
Lung Neoplasms
Middle Aged
العنوانBreast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
النوعArticle
الصفحات51-58
رقم العدد1
رقم المجلد65
dc.accessType Abstract Only


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