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المؤلفImam, Yahia Z.
المؤلفChandra, Prem
المؤلفSingh, Rajvir
المؤلفHakeem, Ishrat
المؤلفAl Sirhan, Sally
المؤلفKotob, Mona
المؤلفAkhtar, Naveed
المؤلفKamran, Saadat
المؤلفAl Jerdi, Salman
المؤلفMuhammad, Ahmad
المؤلفHaroon, Khawaja Hasan
المؤلفHussain, Suhail
المؤلفPerkins, Jon D.
المؤلفElalamy, Osama
المؤلفAlhatou, Mohamed
المؤلفAli, Liaquat
المؤلفAbdelmoneim, Mohamed S.
المؤلفJoseph, Sujatha
المؤلفMorgan, Deborah
المؤلفUy, Ryan Ty
المؤلفBhutta, Zain
المؤلفAzad, Aftab
المؤلفAyyad, Ali
المؤلفElsotouhy, Ahmed
المؤلفOwn, Ahmed
المؤلفDeleu, Dirk
تاريخ الإتاحة2024-04-25T06:20:13Z
تاريخ النشر2024
اسم المنشورFrontiers in Neurology
المصدرScopus
الرقم المعياري الدولي للكتاب16642295
معرّف المصادر الموحدhttp://dx.doi.org/10.3389/fneur.2024.1302298
معرّف المصادر الموحدhttp://hdl.handle.net/10576/54242
الملخصBackground: Posterior cerebral circulation ischemic stroke (PCS) comprises up to 25% of all strokes. It is characterized by variable presentation, leading to misdiagnosis and morbidity and mortality. We aim to describe PCS in large multiethnic cohorts. Methods: A retrospective review of a large national stroke database from its inception on the 1st of January 2014 till 31 December 2020. Incidence per 100,000 adult population/year, demographics, clinical features, stroke location, and outcomes were retrieved. We divided the cohort into patients from MENA (Middle East and North Africa) and others. Results: In total, 1,571 patients were identified. The incidence of PCS was observed to be rising and ranged from 6.3 to 13.2/100,000 adult population over the study period. Men were 82.4% of the total. The mean age was 54.9 ± 12.7 years (median 54 years, IQR 46, 63). MENA patients comprised 616 (39.2%) while others were 954 (60.7%); of these, the majority (80.5%) were from South Asia. Vascular risk factors were prevalent with 1,230 (78.3%) having hypertension, 970 (61.7%) with diabetes, and 872 (55.5%) having dyslipidemia. Weakness (944, 58.8%), dizziness (801, 50.5%), and slurred speech (584, 36.2%) were the most commonly presenting symptoms. The mean National Institute of Health Stroke Score (NIHSS) score was 3.8 ± 4.6 (median 3, IQR 1, 5). The overall most frequent stroke location was the distal location (568, 36.2%). The non-MENA cohort was younger, less vascularly burdened, and had more frequent proximal stroke location (p < 0.05). Dependency or death at discharge was seen in 39.5% and was associated with increasing age, and proximal and multilocation involvement; while at 90 days it was 27.4% and was associated with age, male sex, and having a MENA nationality (p < 0.05). Conclusion: In a multiethnic cohort of posterior circulation stroke patients from the MENA region and South Asia, we noted a rising incidence over time, high prevalence of vascular risk factors, and poor outcomes in older men from the MENA region. We also uncovered considerable disparities between the MENA and non-MENA groups in stroke location and outcome. These disparities are crucial factors to consider when tailoring individualized patient care plans. Further research is needed to thoroughly investigate the underlying reasons for these variations.
اللغةen
الناشرFrontiers Media SA
الموضوعclinical features
incidence
multiethnic
observational
outcomes
posterior circulation stroke
العنوانIncidence, clinical features, and outcomes of posterior circulation ischemic stroke: insights from a large multiethnic stroke database
النوعArticle
رقم المجلد15
dc.accessType Open Access


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