Show simple item record

AuthorRayan, Menatallah
AuthorSayed, Tahseen S
AuthorHussein, Ola J
AuthorTherachiyil, Lubna
AuthorMaayah, Zaid H
AuthorMaccalli, Cristina
AuthorUddin, Shahab
AuthorPrehn, Jochen H M
AuthorKorashy, Hesham M
Available date2024-04-28T10:18:36Z
Publication Date2024-03-06
Publication NameCellular and Molecular Biology Letters
Identifierhttp://dx.doi.org/10.1186/s11658-024-00538-0
CitationRayan, M., Sayed, T. S., Hussein, O. J., Therachiyil, L., Maayah, Z. H., Maccalli, C., ... & Korashy, H. M. (2024). Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development. Cellular & Molecular Biology Letters, 29(1), 33.
ISSN1425-8153
URIhttp://hdl.handle.net/10576/54339
AbstractGut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some microbiotas of the gut and oral cavity have been reported to infect tumors, initiate metastasis, and promote the spread of cancer to distant organs, thereby influencing the clinical outcome of cancer patients. The gut microbiome has recently been reported to interact with environmental factors such as diet and exposure to environmental toxicants. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) induces a shift in the gut microbiome metabolic pathways, favoring a proinflammatory microenvironment. In addition, other studies have also correlated cancer incidence with exposure to PAHs. PAHs are known to induce organ carcinogenesis through activating a ligand-activated transcriptional factor termed the aryl hydrocarbon receptor (AhR), which metabolizes PAHs to highly reactive carcinogenic intermediates. However, the crosstalk between AhR and the microbiome in mediating carcinogenesis is poorly reviewed. This review aims to discuss the role of exposure to environmental pollutants and activation of AhR on microbiome-associated cancer progression and explore the underlying molecular mechanisms involved in cancer development.
SponsorOpen Access funding provided by the Qatar National Library. This study was supported by Qatar University Internal grant nos. IRCC-2022-484 and QUCG-CPH-23/24-154.
Languageen
PublisherSpringer Nature
SubjectAryl hydrocarbon receptor
CYP1A1
Cancer
Environmental pollutants
Microbiome
TitleUnlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development.
TypeArticle
Issue Number1
Volume Number29
ESSN1689-1392
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record