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المؤلفTurner, S.J.
المؤلفSenol, E.
المؤلفKara, A.
المؤلفAl-Badriyeh, D.
المؤلفKong, D.C.M.
المؤلفDinleyici, E.C.
تاريخ الإتاحة2024-04-30T05:47:45Z
تاريخ النشر2013
اسم المنشورInternational Journal of Antimicrobial Agents
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.ijantimicag.2013.04.030
الرقم المعياري الدولي للكتاب9248579
معرّف المصادر الموحدhttp://hdl.handle.net/10576/54477
الملخصInvasive fungal infections (IFIs) are a major concern within healthcare systems. This pharmacoeconomic study evaluated the use of caspofungin (CAS) versus liposomal amphotericin B (L-AmB) in the empirical treatment of IFIs within the Turkish healthcare system. A decision-analytic model was adopted, utilising data from a randomised, non-inferiority clinical trial and a panel of clinical experts in Turkey. A five-point composite outcome measure was used to evaluate both agents. Sensitivity analyses were performed. In the base-case scenario, CAS was preferred over L-AmB by Turkish Lira (TL) 3961 per patient treated, TL 12 904 per successfully treated patient and TL 3972 per death averted. One-way sensitivity analysis did not change the study outcome. Monte Carlo simulation concluded a 71.0% chance of the outcome favouring CAS. The results were most sensitive to changes in length of stay. This is the first economic evaluation of the empirical treatment of IFIs in Turkey and suggests that CAS is more cost effective than L-AmB.
اللغةen
الناشرElsevier
الموضوعAntifungal agents
Caspofungin
Economic evaluation
Empirical therapy
Invasive fungal infection
Liposomal amphotericin B
العنوانPharmacoeconomic evaluation of caspofungin versus liposomal amphotericin B in empirical treatment of invasive fungal infections in Turkey
النوعArticle
الصفحات276-280
رقم العدد3
رقم المجلد42
dc.accessType Abstract Only


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