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المؤلفDenham, Joshua
المؤلفSellami, Maha
تاريخ الإتاحة2024-05-05T08:58:55Z
تاريخ النشر2021
اسم المنشورAgeing Research Reviews
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.arr.2021.101411
الرقم المعياري الدولي للكتاب15681637
معرّف المصادر الموحدhttp://hdl.handle.net/10576/54623
الملخصTelomeres protect genomic stability and shortening is one of the hallmarks of ageing. Telomerase reverse transcriptase (TERT) is the major protein component of telomerase, which elongates telomeres. Given that short telomeres are linked to a host of chronic diseases and the therapeutic potential of telomerase-based therapies as treatments and a strategy to extend lifespan, lifestyle factors that increase TERT gene expression and telomerase activity could attenuate telomere attrition and contribute to healthy biological ageing. Physical activity and maximal aerobic fitness are associated with telomere maintenance, yet the molecular mechanisms remain unclear. Therefore, the purpose of this systematic review and meta-analysis was to identify the influence of a single bout of exercise and long-term exercise training on TERT expression and telomerase activity. A search of human and rodent trials using the PubMed, Scopus, Science Direct and Embase databases was performed. Based on findings from the identified and eligible trials, both a single bout of exercise (n; standardised mean difference [95%CI]: 5; SMD: 1.19 [0.41-1.97], p = 0.003) and long-term exercise training (10; 0.31 [0.03-0.60], p = 0.03) up-regulates TERT and telomerase activity in non-cancerous somatic cells. As human and rodent studies were included in the meta-analyses both exhibited heterogeneity (I2 = 55-87%, p < 0.05). Endurance athletes also exhibited increased leukocyte TERT and telomerase activity compared to their inactive counterparts. These findings suggest exercise training as an inexpensive lifestyle factor that increases TERT expression and telomerase activity. Regular exercise training could attenuate telomere attrition through a telomerase-dependent mechanism and ultimately extend health-span and longevity.
راعي المشروعThe authors thank the researchers who shared their data to support the meta-analyses in the present study.
اللغةen
الناشرElsevier
الموضوعbiological ageing
senescence
Telomere
TERT
العنوانExercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis
النوعArticle Review
رقم المجلد70
dc.accessType Abstract Only


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