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AuthorDenham, Joshua
AuthorMcCluskey, Michael
AuthorDenham, Michele M.
AuthorSellami, Maha
AuthorDavie, Allan J.
Available date2024-05-05T08:58:55Z
Publication Date2021
Publication NameEquine Veterinary Journal
ResourceScopus
Identifierhttp://dx.doi.org/10.1111/evj.13320
ISSN4251644
URIhttp://hdl.handle.net/10576/54624
AbstractHorses (Equus ferus caballus) have evolved over the past 300 years in response to man-made selection for particular athletic traits. Some of the selected traits were selected based on the size and horses' muscular power (eg Clydesdales), whereas other breeds were bred for peak running performance (eg Thoroughbred and Arabian). Although the physiological changes and some of the cellular adaptations responsible for athletic potential of horses have been identified, the molecular mechanisms are only just beginning to be comprehensively investigated. The purpose of this review was to outline and discuss the current understanding of the molecular mechanisms underpinning the athletic performance and cardiorespiratory fitness in athletic breeds of horses. A brief review of the biology of epigenetics is provided, including discussion on DNA methylation, histone modifications and small RNAs, followed by a summary and critical review of the current work on the exercise-induced epigenetic and transcriptional changes in horses. Important unanswered questions and currently unexplored areas that deserve attention are highlighted. Finally, a rationale for the analysis of epigenetic modifications in the context with exercise-related traits and ailments associated with athletic breeds of horses is outlined in order to help guide future research.
Languageen
PublisherEquine Veterinary Journal Ltd
Subjectepigenetic modifications
Equus caballus
gene
horse
racehorse
small RNAs
TitleEpigenetic control of exercise adaptations in the equine athlete: Current evidence and future directions
TypeArticle
Pagination431-450
Issue Number3
Volume Number53


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