A Promising Electrochemical Sensor Platform for the Detection of Dopamine Using CuO-NiO/rGO Composite
Author | Krishnasamy, Vinotha |
Author | Nair, Gayathri Geetha |
Author | Sha, Mizaj Shabil |
Author | Kannan, Karthik |
Author | Al-maadeed, Somaya |
Author | Muthalif, Asan G.A. |
Author | Sadasivuni, Kishor Kumar |
Available date | 2024-05-14T03:51:40Z |
Publication Date | 2023 |
Publication Name | Macromolecular Symposia |
Resource | Scopus |
Identifier | http://dx.doi.org/10.1002/masy.202200151 |
ISSN | 10221360 |
Abstract | Dopamine plays a significant role in the proper functioning of the central nervous system. Hence, the ability to sense levels of dopamine is pivotal in diagnosis and treatment procedures. For sensing dopamine, a mixed metal oxide nanocomposite (NC) of copper oxide-nickel oxide/reduced graphene oxide (CuO-NiO/rGO) is fabricated by the sol–gel method, and it is used to modify the glassy carbon electrode. The structural and morphological characterizations are done by X-ray diffraction (XRD), Energy dispersive X-ray (EDAX), Raman, and Scanning electron microscopy (SEM). XRD results exhibit monoclinic CuO, cubic NiO, and hexagonal rGO structures. The Raman studies confirm the D and G bands for rGO. Different electrochemical techniques are used to examine the efficacy of nanocomposite in detecting dopamine. The CuO-NiO metal oxide NC response compared with the CuO-NiO/rGO NC shows a better response by rGO containing nanocomposite. Further, the chronoamperometric method is employed, and the diffusion coefficient is calculated as 1.04 × 10−6 cm2 s−1. The differential pulse voltammetry is carried out to measure the nanocomposite's sensitivity and detection limit (LOD). The catalyst exhibits a sensitivity of 7.2 µA cm−2 mM−1 and a LOD of 0.006 µM. The composite can be used as a flexible skin patch sensor to predict abnormal dopamine levels such as Parkinson's disease. |
Sponsor | This publication was supported by Qatar University internal grant No. QUCG-CAM-21/22-1. The findings herein are solely the responsibility of the authors. |
Language | en |
Publisher | John Wiley and Sons Inc |
Subject | amperometric studies mixed metal oxide nanocomposite proton conductor voltammetry |
Type | Article |
Issue Number | 1 |
Volume Number | 412 |
Files in this item
This item appears in the following Collection(s)
-
Center for Advanced Materials Research [1349 items ]
-
Computer Science & Engineering [2284 items ]
-
Mechanical & Industrial Engineering [1339 items ]