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AuthorRajagopal Padma, M.
AuthorDinesh, Prameela
AuthorSundaresan, Rajesh
AuthorAthreya, Siva
AuthorShiju, Shilpa
AuthorMaroor, Parimala S.
AuthorLalitha Hande, R.
AuthorAkhtar, Jawaid
AuthorChandra, Trilok
AuthorRavi, Deepa
AuthorLobo, Eunice
AuthorAna, Yamuna
AuthorShriyan, Prafulla
AuthorDesai, Anita
AuthorRangaiah, Ambica
AuthorMunivenkatappa, Ashok
AuthorKrishna, S.
AuthorBasawarajappa, Shantala Gowdara
AuthorSreedhara, H.G.
AuthorSiddesh, K.C.
AuthorKumari, B. Amrutha
AuthorUmar, Nawaz
AuthorMythri, B.A.
AuthorMythri, K.M.
AuthorSudarshan, Mysore Kalappa
AuthorVasanthapuram, Ravi
AuthorRathnaiah Babu, Giridhara
Available date2024-05-19T11:23:06Z
Publication Date2024
Publication NameIJID Regions
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.ijregi.2021.10.008
ISSN27727076
URIhttp://hdl.handle.net/10576/55111
AbstractObjective Demonstrate the feasibility of using the existing sentinel surveillance infrastructure to conduct the second round of the serial cross-sectional sentinel-based population survey. Assess active infection, seroprevalence, and their evolution in the general population across Karnataka. Identify local variations for locally appropriate actions. Additionally, assess the clinical sensitivity of the testing kit used on account of variability of antibody levels in the population. Methods The cross-sectional study of 41,228 participants across 290 healthcare facilities in all 30 districts of Karnataka was done among three groups of participants (low, moderate, and high-risk). The geographical spread was sufficient to capture local variations. Consenting participants were subjected to real-time reverse transcription-polymerase chain reaction (RT-PCR) testing, and antibody (IgG) testing. Clinical sensitivity was assessed by conducting a longitudinal study among participants identified as COVID-19 positive in the first survey round. Results Overall weighted adjusted seroprevalence of IgG was 15.6% (95% CI: 14.9–16.3), crude IgG prevalence was 15.0% and crude active infection was 0.5%. Statewide infection fatality rate (IFR) was estimated as 0.11%, and COVID-19 burden estimated between 26.1 to 37.7% (at 90% confidence). Further, Cases-to-infections ratio (CIR) varied 3-35 across units and IFR varied 0.04–0.50% across units. Clinical sensitivity of the IgG ELISA test kit was estimated as ≥38.9%. Conclusion We demonstrated the feasibility and simplicity of sentinel-based population survey in measuring variations in subnational and local data, useful for locally appropriate actions in different locations. The sentinel-based population survey thus helped identify districts that needed better testing, reporting, and clinical management. The state was far from attaining natural immunity during the survey and hence must step up vaccination coverage and enforce public health measures to prevent the spread of COVD-19.
SponsorThe Institutional Ethics Committee (IEC) of the Indian Institute of Public Health - Bengaluru campus reviewed and approved the study (vide. IIPHHB/TRCIEC/174/2020) and the subsequent change of protocol to perform the longitudinal study (vide PHFI/IIPH-BLR/076/2020-21). We informed the participants of the purpose of the surveys, how the samples would be taken and requested them to respond to the screening questions. After obtaining informed consent, we noted basic demographic details, exposure history, symptoms observed in the previous month, and clinical history. Participants' test results were shared with them by the concerned healthcare facility.
Languageen
PublisherElsevier
SubjectSARS-CoV-2
sentinel survey
clinical sensitivity
serosurvey
Karnataka
TitleSecond round statewide sentinel-based population survey for estimation of the burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population of Karnataka, India, during January-February 2021
TypeArticle
Pagination107-116
Volume Number10
dc.accessType Open Access


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