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AuthorMustafa, Imtiaz
AuthorFaisal, Muhammad Naeem
AuthorHussain, Ghulam
AuthorMuzaffar, Humaira
AuthorImran, Muhammad
AuthorIjaz, Muhammad Umar
AuthorSohail, Muhammad Umar
AuthorIftikhar, Arslan
AuthorShaukat, Arslan
AuthorAnwar, Haseeb
Available date2024-06-03T11:09:41Z
Publication Date2021-02-12
Publication NameBMC Complementary Medicine and Therapies
Identifierhttp://dx.doi.org/10.1186/s12906-021-03237-x
CitationMustafa, I., Faisal, M. N., Hussain, G., Muzaffar, H., Imran, M., Ijaz, M. U., ... & Anwar, H. (2021). Efficacy of Euphorbia helioscopia in context to a possible connection between antioxidant and antidiabetic activities: a comparative study of different extracts. BMC Complementary Medicine and Therapies, 21, 1-12.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85100867930&origin=inward
URIhttp://hdl.handle.net/10576/55786
AbstractBackground: Euphorbia helioscopia, conventionally known as sun spurge, has been used as a traditional medicine to treat different diseases owing to its reported antitumor, antiviral and antioxidant activities. Methods: The current research was formulated to assess the in-vitro antioxidant and antidiabetic ability of Euphorbia helioscopia subsequent to the phytochemical analysis of its various extracts. For this purpose, methanol, ethanol and aqueous extracts were prepared using the whole dried plant. Phytochemical analysis of the extracts was done to evaluate the total flavonoid components (TFC) and total phenolic components (TPC) in the extracts. A total of seven phenolic and three flavonoid contents were documented and quantified using HPLC. Antioxidant values were found by DPPH assay, FRAP and ABTS assays. The antidiabetic potential of the extracts was evaluated by measuring the inhibition ability of the activity of enzymes α amylase and α glucosidase. Results: After analyzing statistically, the results showed that methanolic extract possesses the highest TFC and TPC values while aqueous extract encompassed the lowest level of these contents. Invitro results showed that methanolic extract of the Euphorbia helioscopia has the maximum antioxidant capability since it showed the highest scavenging ability towards the DPPH (IC50 value = 0.06 ± 0.02 mg/ml), FRAP (758.9 ± 25.1 μMFe+ 2/g), and ABTS (689 ± 25.94 μMTEq/g) due to the presence of high TPC (24.77 ± 0.35 mgGAEq/g) and TFC (17.95 ± 0.32 mgQEq/g) values. Antidiabetic activity in terms of inhibition potential of α amylase and α glucosidase activity was also observed maximum in methanolic extract having lowest IC50 value (0.4 ± 0.01 mg/ml and 0.45 ± 0.01 mg/ml respectively) and minimum in the aqueous extract (IC50 value = 0.57 ± 0.02 mg/ml and 0.76 ± 0.1 mg/ml respectively). Conclusion: The experiment outcomes have shown that Euphorbia helioscopia extracts used in the current study contain antioxidant and antidiabetic activities; however, it is highest in its methanolic extract. The presence of the same trend towards the highest antidiabetic activity of the methanolic extract in terms of maximum inhibiting activity of α amylase and α glucosidase enzymes suggests a close association of TFC and TPC in minimizing diabetes.
Languageen
PublisherSpringer Nature
SubjectAntidiabetic
Antioxidant
Euphorbia helioscopia
Methanolic extract
TitleEfficacy of Euphorbia helioscopia in context to a possible connection between antioxidant and antidiabetic activities: a comparative study of different extracts
TypeArticle
Pagination1-12
Issue Number1
Volume Number21
ESSN2662-7671
dc.accessType Open Access


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