Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050
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| Author | Tesler, Riki |
| Author | Thapar, Rekha |
| Author | Tharwat, Samar |
| Author | Thayakaran, Rasiah |
| Author | Ticoalu, Jansje Henny Vera |
| Author | Tovani-Palone, Marcos Roberto |
| Author | Tusa, Biruk Shalmeno |
| Author | Ty, Sree Sudha |
| Author | Udoakang, Aniefiok John |
| Author | Vahabi, Seyed Mohammad |
| Author | Valizadeh, Rohollah |
| Author | Van den Eynde, Jef |
| Author | Varthya, Shoban Babu |
| Author | Vasankari, Tommi Juhani |
| Author | Venketasubramanian, Narayanaswamy |
| Author | Villafañe, Jorge Hugo |
| Author | Vlassov, Vasily |
| Author | Vo, Anh Truc |
| Author | Vu, Linh Gia |
| Author | Wang, Yuan-Pang |
| Author | Wiangkham, Taweewat |
| Author | Wickramasinghe, Nuwan Darshana |
| Author | Winkler, Andrea Sylvia |
| Author | Wu, Ai-Min |
| Author | Yadollahpour, Ali |
| Author | Yahya, Galal |
| Author | Yonemoto, Naohiro |
| Author | You, Yuyi |
| Author | Younis, Mustafa Z. |
| Author | Zakham, Fathiah |
| Author | Zangiabadian, Moein |
| Author | Zarrintan, Armin |
| Author | Zhong, Chenwen |
| Author | Zhou, Hengxing |
| Author | Zhu, Zhaochen |
| Author | Zielińska, Magdalena |
| Author | Zikarg, Yossef Teshome |
| Author | Zitoun, Osama A. |
| Author | Zoladl, Mohammad |
| Author | Tam, Lai-Shan |
| Author | Wu, Dongze |
| Available date | 2024-06-10T04:27:54Z |
| Publication Date | 2024-06-03 |
| Publication Name | Med |
| Identifier | http://dx.doi.org/10.1016/j.medj.2024.04.009 |
| ISSN | 2666-6359 |
| Abstract | BackgroundThis study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 to 39 years. MethodsThe global prevalence, years lived with disabilities (YLDs), disability-adjusted life years (DALYs), projection, and inequality were estimated for early MSK diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), low back pain (LBP), neck pain (NP), gout, and other MSK diseases (OMSKDs). FindingsMore adolescents and young adults were expected to develop MSK disorders by 2050. Across five age groups, the rates of prevalence, YLDs, and DALYs for RA, NP, LBP, gout, and OMSKDs sharply increased from ages 15–19 to 35–39; however, these were negligible for OA before age 30 but increased notably at ages 30–34, rising at least 6-fold by 35–39. The disease burden of gout, LBP, and OA attributable to high BMI and gout attributable to kidney dysfunction increased, while the contribution of smoking to LBP and RA and occupational ergonomic factors to LBP decreased. Between 1990 and 2019, the slope index of inequality increased for six MSK disorders, and the relative concentration index increased for gout, NP, OA, and OMSKDs but decreased for LBP and RA. ConclusionsMultilevel interventions should be initiated to prevent disease burden related to RA, NP, LBP, gout, and OMSKDs among individuals ages 15–19 and to OA among individuals ages 30–34 to tightly control high BMI and kidney dysfunction. FundingThe Global Burden of Disease study is funded by the Bill and Melinda Gates Foundation. The project is funded by the Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital (2022QN38). |
| Sponsor | This study was produced as part of the GBD Collaborator Network and in accordance with the GBD Protocol (IHME ID: 4241-GBD2019). For GBD studies, a waiver of informed consent was reviewed and approved by the Institutional Review Board of the University of Washington. The Global Burden of Disease study is funded by the Bill and Melinda Gates Foundation. The project is funded by the Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital (2022QN38). Y.J. and C.G. were joint first authors who contributed equally to the manuscript. L.-s.T. and D.W. were joint senior authors. Y.J., C.G., L.-s.T., and D.W. were writing authors of the manuscript. |
| Language | en |
| Publisher | Elsevier |
| Subject | musculoskeletal disorders Global Burden of Disease study trend inequality pattern rheumatoid arthritis osteoarthritis gout low back pain neck pain |
| Type | Article |
| Open Access user License | http://creativecommons.org/licenses/by/4.0/ |
| ESSN | 26666340 |
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