Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
التاريخ
2021-12-01المؤلف
Razali, Rozaimi MohamadRodriguez-Flores, Juan
Ghorbani, Mohammadmersad
Naeem, Haroon
Aamer, Waleed
Aliyev, Elbay
Jubran, Ali
Ismail, Said I.
Al-Muftah, Wadha
Badji, Radja
Mbarek, Hamdi
Darwish, Dima
Fadl, Tasnim
Yasin, Heba
Ennaifar, Maryem
Abdellatif, Rania
Alkuwari, Fatima
Alvi, Muhammad
Al-Sarraj, Yasser
Saad, Chadi
Althani, Asmaa
Fethnou, Eleni
Qafoud, Fatima
Alkhayat, Eiman
Afifi, Nahla
Tomei, Sara
Liu, Wei
Lorenz, Stephan
Syed, Najeeb
Almabrazi, Hakeem
Vempalli, Fazulur Rehaman
Temanni, Ramzi
Saqri, Tariq Abu
Khatib, Mohammedhusen
Hamza, Mehshad
Zaid, Tariq Abu
El Khouly, Ahmed
Pathare, Tushar
Poolat, Shafeeq
Al-Ali, Rashid
Albagha, Omar
Al-Khodor, Souhaila
Alshafai, Mashael
Badii, Ramin
Chouchane, Lotfi
Estivill, Xavier
Fakhro, Khalid A.
Mokrab, Younes
Puthen, Jithesh V.
Suhre, Karsten
Tatari, Zohreh
Clark, Andrew G.
...show more authors ...show less authors
البيانات الوصفية
عرض كامل للتسجيلةالملخص
Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries representing the main founding Arab genealogical lineages of Qahtanite (Peninsular Arabs) and Adnanite (General Arabs and West Eurasian Arabs). We find that Peninsular Arabs are the closest relatives of ancient hunter-gatherers and Neolithic farmers from the Levant, and that founder Arab populations experienced multiple splitting events 12–20 kya, consistent with the aridification of Arabia and farming in the Levant, giving rise to settler and nomadic communities. In terms of recent genetic flow, we show that these ancestries contributed significantly to European, South Asian as well as South American populations, likely as a result of Islamic expansion over the past 1400 years. Notably, we characterize a large cohort of men with the ChrY J1a2b haplogroup (n = 1,491), identifying 29 unique sub-haplogroups. Finally, we leverage genotype novelty to build a reference panel of 12,432 haplotypes, demonstrating improved genotype imputation for both rare and common alleles in Arabs and the wider Middle East.
معرّف المصادر الموحد
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85118396665&origin=inwardالمجموعات
- العلوم الحيوية الطبية [692 items ]