عرض بسيط للتسجيلة

المؤلفRazali, Rozaimi Mohamad
المؤلفRodriguez-Flores, Juan
المؤلفGhorbani, Mohammadmersad
المؤلفNaeem, Haroon
المؤلفAamer, Waleed
المؤلفAliyev, Elbay
المؤلفJubran, Ali
المؤلفIsmail, Said I.
المؤلفAl-Muftah, Wadha
المؤلفBadji, Radja
المؤلفMbarek, Hamdi
المؤلفDarwish, Dima
المؤلفFadl, Tasnim
المؤلفYasin, Heba
المؤلفEnnaifar, Maryem
المؤلفAbdellatif, Rania
المؤلفAlkuwari, Fatima
المؤلفAlvi, Muhammad
المؤلفAl-Sarraj, Yasser
المؤلفSaad, Chadi
المؤلفAlthani, Asmaa
المؤلفFethnou, Eleni
المؤلفQafoud, Fatima
المؤلفAlkhayat, Eiman
المؤلفAfifi, Nahla
المؤلفTomei, Sara
المؤلفLiu, Wei
المؤلفLorenz, Stephan
المؤلفSyed, Najeeb
المؤلفAlmabrazi, Hakeem
المؤلفVempalli, Fazulur Rehaman
المؤلفTemanni, Ramzi
المؤلفSaqri, Tariq Abu
المؤلفKhatib, Mohammedhusen
المؤلفHamza, Mehshad
المؤلفZaid, Tariq Abu
المؤلفEl Khouly, Ahmed
المؤلفPathare, Tushar
المؤلفPoolat, Shafeeq
المؤلفAl-Ali, Rashid
المؤلفAlbagha, Omar
المؤلفAl-Khodor, Souhaila
المؤلفAlshafai, Mashael
المؤلفBadii, Ramin
المؤلفChouchane, Lotfi
المؤلفEstivill, Xavier
المؤلفFakhro, Khalid A.
المؤلفMokrab, Younes
المؤلفPuthen, Jithesh V.
المؤلفSuhre, Karsten
المؤلفTatari, Zohreh
المؤلفClark, Andrew G.
تاريخ الإتاحة2024-06-12T08:27:43Z
تاريخ النشر2021-12-01
اسم المنشورNature Communications
المعرّفhttp://dx.doi.org/10.1038/s41467-021-25287-y
الاقتباسRazali, R. M., Rodriguez-Flores, J., Ghorbani, M., Naeem, H., Aamer, W., Aliyev, E., ... & Data Management and Computing Infrastructure group Saqri Tariq Abu 10 Khatib Mohammedhusen 10 Hamza Mehshad 10 Zaid Tariq Abu 10 El Khouly Ahmed 10 Pathare Tushar 10 Poolat Shafeeq 10 Al-Ali Rashid 10. (2021). Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes. Nature Communications, 12(1), 5929.‏
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85118396665&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/56109
الملخصArab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries representing the main founding Arab genealogical lineages of Qahtanite (Peninsular Arabs) and Adnanite (General Arabs and West Eurasian Arabs). We find that Peninsular Arabs are the closest relatives of ancient hunter-gatherers and Neolithic farmers from the Levant, and that founder Arab populations experienced multiple splitting events 12–20 kya, consistent with the aridification of Arabia and farming in the Levant, giving rise to settler and nomadic communities. In terms of recent genetic flow, we show that these ancestries contributed significantly to European, South Asian as well as South American populations, likely as a result of Islamic expansion over the past 1400 years. Notably, we characterize a large cohort of men with the ChrY J1a2b haplogroup (n = 1,491), identifying 29 unique sub-haplogroups. Finally, we leverage genotype novelty to build a reference panel of 12,432 haplotypes, demonstrating improved genotype imputation for both rare and common alleles in Arabs and the wider Middle East.
اللغةen
الناشرNature Research
الموضوعQatari
العنوانThousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
النوعArticle
رقم العدد1
رقم المجلد12
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة