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AuthorRazali, Rozaimi Mohamad
AuthorRodriguez-Flores, Juan
AuthorGhorbani, Mohammadmersad
AuthorNaeem, Haroon
AuthorAamer, Waleed
AuthorAliyev, Elbay
AuthorJubran, Ali
AuthorIsmail, Said I.
AuthorAl-Muftah, Wadha
AuthorBadji, Radja
AuthorMbarek, Hamdi
AuthorDarwish, Dima
AuthorFadl, Tasnim
AuthorYasin, Heba
AuthorEnnaifar, Maryem
AuthorAbdellatif, Rania
AuthorAlkuwari, Fatima
AuthorAlvi, Muhammad
AuthorAl-Sarraj, Yasser
AuthorSaad, Chadi
AuthorAlthani, Asmaa
AuthorFethnou, Eleni
AuthorQafoud, Fatima
AuthorAlkhayat, Eiman
AuthorAfifi, Nahla
AuthorTomei, Sara
AuthorLiu, Wei
AuthorLorenz, Stephan
AuthorSyed, Najeeb
AuthorAlmabrazi, Hakeem
AuthorVempalli, Fazulur Rehaman
AuthorTemanni, Ramzi
AuthorSaqri, Tariq Abu
AuthorKhatib, Mohammedhusen
AuthorHamza, Mehshad
AuthorZaid, Tariq Abu
AuthorEl Khouly, Ahmed
AuthorPathare, Tushar
AuthorPoolat, Shafeeq
AuthorAl-Ali, Rashid
AuthorAlbagha, Omar
AuthorAl-Khodor, Souhaila
AuthorAlshafai, Mashael
AuthorBadii, Ramin
AuthorChouchane, Lotfi
AuthorEstivill, Xavier
AuthorFakhro, Khalid A.
AuthorMokrab, Younes
AuthorPuthen, Jithesh V.
AuthorSuhre, Karsten
AuthorTatari, Zohreh
AuthorClark, Andrew G.
Available date2024-06-12T08:27:43Z
Publication Date2021-12-01
Publication NameNature Communications
Identifierhttp://dx.doi.org/10.1038/s41467-021-25287-y
CitationRazali, R. M., Rodriguez-Flores, J., Ghorbani, M., Naeem, H., Aamer, W., Aliyev, E., ... & Data Management and Computing Infrastructure group Saqri Tariq Abu 10 Khatib Mohammedhusen 10 Hamza Mehshad 10 Zaid Tariq Abu 10 El Khouly Ahmed 10 Pathare Tushar 10 Poolat Shafeeq 10 Al-Ali Rashid 10. (2021). Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes. Nature Communications, 12(1), 5929.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85118396665&origin=inward
URIhttp://hdl.handle.net/10576/56109
AbstractArab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries representing the main founding Arab genealogical lineages of Qahtanite (Peninsular Arabs) and Adnanite (General Arabs and West Eurasian Arabs). We find that Peninsular Arabs are the closest relatives of ancient hunter-gatherers and Neolithic farmers from the Levant, and that founder Arab populations experienced multiple splitting events 12–20 kya, consistent with the aridification of Arabia and farming in the Levant, giving rise to settler and nomadic communities. In terms of recent genetic flow, we show that these ancestries contributed significantly to European, South Asian as well as South American populations, likely as a result of Islamic expansion over the past 1400 years. Notably, we characterize a large cohort of men with the ChrY J1a2b haplogroup (n = 1,491), identifying 29 unique sub-haplogroups. Finally, we leverage genotype novelty to build a reference panel of 12,432 haplotypes, demonstrating improved genotype imputation for both rare and common alleles in Arabs and the wider Middle East.
Languageen
PublisherNature Research
SubjectQatari
TitleThousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
TypeArticle
Issue Number1
Volume Number12
dc.accessType Abstract Only


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