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المؤلفAdegboye, Oyelola A
المؤلفGayawan, Ezra
المؤلفHanna, Fahad
تاريخ الإتاحة2017-08-08T09:08:16Z
تاريخ النشر2017-07-31
اسم المنشورPLoS ONE
المعرّفhttp://dx.doi.org/10.1371/journal.pone.0181215
الاقتباسAdegboye OA, Gayawan E, Hanna F (2017) Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula. PLoS ONE 12(7): e0181215. https://doi.org/10.1371/journal.pone.0181215
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5613
الملخصMiddle East respiratory syndrome coronavirus is a contagious respiratory pathogen that is contracted via close contact with an infected subject. Transmission of the pathogen has occurred through animal-to-human contact at first followed by human-to-human contact within families and health care facilities. This study is based on a retrospective analysis of the Middle East respiratory syndrome coronavirus outbreak in the Kingdom of Saudi Arabia between June 2012 and July 2015. A Geoadditive variable model for binary outcomes was applied to account for both individual level risk factors as well spatial variation via a fully Bayesian approach. Out of 959 confirmed cases, 642 (67%) were males and 317 (33%) had died. Three hundred and sixty four (38%) cases occurred in Ar Riyad province, while 325 (34%) cases occurred in Makkah. Individuals with some comorbidity had a significantly higher likelihood of dying from MERS-CoV compared with those who did not suffer comorbidity [Odds ratio (OR) = 2.071; 95% confidence interval (CI): 1.307, 3.263]. Health-care workers were significantly less likely to die from the disease compared with non-health workers [OR = 0.372, 95% CI: 0.151, 0.827]. Patients who had fatal clinical experience and those with clinical and subclinical experiences were equally less likely to die from the disease compared with patients who did not have fatal clinical experience and those without clinical and subclinical experiences respectively. The odds of dying from the disease was found to increase as age increased beyond 25 years and was much higher for individuals with any underlying comorbidities. Interventions to minimize mortality from the Middle East respiratory syndrome coronavirus should particularly focus individuals with comorbidity, non-health-care workers, patients with no clinical fatal experience, and patients without any clinical and subclinical experiences.
راعي المشروعThe authors received no specific funding for this work. All data analyzed in this study were publicly available.
اللغةen
الناشرPublic Library of Science
الموضوعMiddle East Respiratory Syndrome Coronavirus
Geoadditive Models
Spatial correlation
العنوانSpatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula.
النوعArticle
رقم العدد7
رقم المجلد12
ESSN1932-6203
dc.accessType Open Access


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