Epidemiology of urinary tract infection in adults caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae - a case-control study from Qatar
Author | Naushad, Vamanjore A. |
Author | Purayil, Nishan K. |
Author | Wilson, Godwin J. |
Author | Chandra, Prem |
Author | Joseph, Prakash |
Author | Khalil, Zahida |
Author | Zahid, Muhammad |
Author | Kayakkool, Muhammed K. |
Author | Shaik, NoorJahan |
Author | Ayari, Basma |
Author | Chalihadan, Sajid |
Author | Elmagboul, Emad Basheir I. |
Author | Doiphode, Sanjay H. |
Available date | 2024-07-22T09:19:58Z |
Publication Date | 2022 |
Publication Name | IJID Regions |
Resource | Scopus |
Identifier | http://dx.doi.org/10.1016/j.ijregi.2022.05.001 |
ISSN | 27727076 |
Abstract | Background: Community-acquired urinary tract infection (UTI) is the most common infection caused by extended-spectrum beta-lactamase (ESBL)-producing organisms. Aim: to estimate the prevalence of ESBL-UTI in adults and to identify potential risk factors that may predispose to ESBL-UTI. Methods: A retrospective study involving adult patients with UTI caused by ESBL-producing organisms was undertaken. Patients with UTI caused by non-ESBL-producing organisms represented the control group. Results: In total, 1100 UTI isolates were included in the study, 277 of which were ESBL positive. The prevalence rate was 25.2%. The mean age of patients was 55.87 years. On univariate analysis, prior history of UTI or ESBL-UTI, invasive urological procedure within preceding 3 months, hospital admission within preceding 3 months, and exposure to antibiotics were found to be significant risk factors for ESBL-UTI. On multi-variate analysis, use of cephalosporins [adjusted odds ratio (OR) 1.61, P=0.048], previous ESBL-UTI (adjusted OR 2.67, P<0.001), and invasive urological procedure in the preceding year (adjusted OR 1.61, P=0.022) were found to be independent risk factors for ESBL-UTI. Conclusions: In Qatar, the prevalence of ESBL-UTI in adults is modest. Recent exposure to antibiotics, previous ESBL-UTI and invasive urological procedures were found to be independent risk factors for ESBL-UTI. |
Sponsor | None. This study was approved by the Institutional Review Board of Medical Research Centre, Hamad Medical Corporation (Approval No. MRC-01-20-006). |
Language | en |
Publisher | Elsevier |
Subject | Antibiotics ESBL Extended-spectrum beta-lactamase Urinary tract infections |
Type | Article |
Pagination | 278-286 |
Volume Number | 3 |
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