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المؤلفTurgeon, Ricky D.
المؤلفWilby, Kyle J.
المؤلفEnsom, Mary H.H.
تاريخ الإتاحة2017-10-24T06:59:23Z
تاريخ النشر2015-06
اسم المنشورThe American Journal of Medicine
المعرّفhttp://dx.doi.org/10.1016/j.amjmed.2014.11.033
الاقتباسRicky D. Turgeon, Kyle J. Wilby, Mary H.H. Ensom, "Antiviral Treatment of Bell's Palsy Based on Baseline Severity: A Systematic Review and Meta-analysis", The American Journal of Medicine, Volume 128, Issue 6, 2015, Pages 617-628
الرقم المعياري الدولي للكتاب00029343
معرّف المصادر الموحدhttp://www.sciencedirect.com/science/article/pii/S0002934314012157
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5714
الملخصPurposeWe conducted a systematic review with meta-analysis to evaluate the efficacy of antiviral agents on complete recovery of Bell's palsy. MethodsWe searched CENTRAL, Embase, MEDLINE, International Pharmaceutical Abstracts, and sources of unpublished literature to November 1, 2014. Primary and secondary outcomes were complete and satisfactory recovery, respectively. To evaluate statistical heterogeneity, we performed subgroup analysis of baseline severity of Bell's palsy and between-study sensitivity analyses based on risk of allocation and detection bias. ResultsThe 10 included randomized controlled trials (2419 patients; 807 with severe Bell's palsy at onset) had variable risk of bias, with 9 trials having a high risk of bias in at least 1 domain. Complete recovery was not statistically significantly greater with antiviral use versus no antiviral use in the random-effects meta-analysis of 6 trials (relative risk, 1.06; 95% confidence interval, 0.97-1.16; I2 = 65%). Conversely, random-effects meta-analysis of 9 trials showed a statistically significant difference in satisfactory recovery (relative risk, 1.10; 95% confidence interval, 1.02-1.18; I2 = 63%). Response to antiviral agents did not differ visually or statistically between patients with severe symptoms at baseline and those with milder disease (test for interaction, P = .11). Sensitivity analyses did not show a clear effect of bias on outcomes. ConclusionsAntiviral agents are not efficacious in increasing the proportion of patients with Bell's palsy who achieved complete recovery, regardless of baseline symptom severity.
اللغةen
الناشرElsevier
الموضوعAntiviral
Bell's palsy
Facial nerve
العنوانAntiviral Treatment of Bell's Palsy Based on Baseline Severity: A Systematic Review and Meta-analysis
النوعArticle
الصفحات617-628
رقم العدد6
رقم المجلد128
dc.accessType Abstract Only


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