Unusual product from the acid-catalyzed one-pot, multicomponent reaction of thiocarbohydrazide, aldehydes, and phenacyl bromides
| Author | Shkoor, Mohanad |
| Author | Al-Abade, Ayahtallah |
| Author | Aleteiwib, Ibtesam |
| Author | Al-Talib, Mahmoud |
| Author | Tashtoush, Hasan |
| Available date | 2017-10-25T06:57:39Z |
| Publication Date | 2017-08-18 |
| Publication Name | Synthetic Communications |
| Identifier | http://dx.doi.org/10.1080/00397911.2017.1332225 |
| Citation | Mohanad Shkoor, Ayahtallah Al-Abade, Ibtesam Aleteiwib, Mahmoud Al-Talib & Hasan Tashtoush "Unusual product from the acid-catalyzed one-pot, multicomponent reaction of thiocarbohydrazide, aldehydes, and phenacyl bromides" Synthetic Communications (2017) Volume 47, Issue 16 |
| ISSN | 00397911 |
| Abstract | A one-pot, three-component protocol for the synthesis of novel five-membered thiazole ring bonded to two hydrazone motifs is described. The acid-catalyzed reaction of one equivalent of thiocarbohydrazide, two equivalents of aromatic aldehydes, and one equivalent of phenacyl bromides afforded the five-membered thiazole ring. The reactions proceed with novel chemoselectivity. Similar reported protocols have always afforded 1,3,4-thiadiazines. |
| Sponsor | The financial support of this work by the Deanship of Graduate Studies and Research at Yarmouk University is highly acknowledged (project no. 29/2014). |
| Language | en |
| Publisher | Taylor & Francis |
| Subject | Chemoselectivity hydrazones multicomponent reaction thiazole thiocarbohydrazide thiocarbohydrazone |
| Type | Article |
| Pagination | 1471-1477 |
| Issue Number | 16 |
| Volume Number | 47 |
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