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المؤلفLetourneau, Ian D
المؤلفAbate, Yohannes Habtegiorgis
المؤلفAbdelmasseh, Michael
المؤلفAbu-Gharbieh, Eman
المؤلفAdane, Tigist Demssew
المؤلفAhinkorah, Bright Opoku
المؤلفAhmad, Aqeel
المؤلفAhmadi, Ali
المؤلفAhmed, Ayman
المؤلفAlhalaiqa, Fadwa Naji
المؤلفAl-Sabah, Salman Khalifah
المؤلفAl-Worafi, Yaser Mohammed
المؤلفAmu, Hubert
المؤلفAndrei, Catalina Liliana
المؤلفAnoushiravani, Amir
المؤلفArabloo, Jalal
المؤلفAravkin, Aleksandr Y
المؤلفAshraf, Tahira
المؤلفAzadnajafabad, Sina
المؤلفBaghcheghi, Nayereh
المؤلفBagherieh, Sara
المؤلفBantie, Berihun Bantie
المؤلفBardhan, Mainak
المؤلفBasile, Guido
المؤلفBayleyegn, Nebiyou Simegnew
المؤلفBehnoush, Amir Hossein
المؤلفBekele, Alehegn
المؤلفBhojaraja, Vijayalakshmi S
المؤلفBijani, Ali
المؤلفBiondi, Antonio
المؤلفBurkart, Katrin
المؤلفChu, Dinh-Toi
المؤلفChukwu, Isaac Sunday
المؤلفCruz-Martins, Natalia
المؤلفDai, Xiaochen
المؤلفDemessa, Berecha Hundessa
المؤلفDhali, Arkadeep
المؤلفDiaz, Daniel
المؤلفDo, Thanh Chi
المؤلفDodangeh, Milad
المؤلفDongarwar, Deepa
المؤلفDsouza, Haneil Larson
المؤلفEkholuenetale, Michael
المؤلفEkundayo, Temitope Cyrus
المؤلفEl Sayed, Iman
المؤلفElhadi, Muhammed
المؤلفFagbamigbe, Adeniyi Francis
المؤلفFakhradiyev, Ildar Ravisovich
المؤلفFerrara, Pietro
المؤلفFetensa, Getahun
المؤلفFischer, Florian
المؤلفGebrehiwot, Mesfin
المؤلفGetachew, Melaku
المؤلفGolechha, Mahaveer
المؤلفGupta, Vivek Kumar
المؤلفHabib, Joseph R
المؤلفHadi, Najah R
المؤلفHaep, Nils
المؤلفHaile, Teklehaimanot Gereziher
المؤلفHamilton, Erin B
المؤلفHasan, Ikramul
المؤلفHasani, Hamidreza
المؤلفHassanzadeh, Sara
المؤلفHaubold, Johannes
المؤلفHay, Simon I
المؤلفHayat, Khezar
المؤلفIlesanmi, Olayinka Stephen
المؤلفInamdar, Sumant
المؤلفIwu, Chidozie C D
المؤلفIyasu, Assefa N
المؤلفJayarajah, Umesh
المؤلفJayaram, Shubha
المؤلفJokar, Mohammad
المؤلفJomehzadeh, Nabi
المؤلفJoseph, Abel
المؤلفJoseph, Nitin
المؤلفJoshua, Charity Ehimwenma
المؤلفKabir, Ali
المؤلفKandel, Himal
المؤلفKauppila, Joonas H
المؤلفKemp Bohan, Phillip M.
المؤلفKhajuria, Himanshu
المؤلفKhan, Maseer
المؤلفKhatatbeh, Haitham
المؤلفKim, Min Seo
المؤلفKisa, Adnan
المؤلفKompani, Farzad
المؤلفKoohestani, Hamid Reza
المؤلفKumar, Rakesh
المؤلفLe, Thao Thi Thu
المؤلفLee, Munjae
المؤلفLee, Seung Won
المؤلفLi, Ming-Chieh
المؤلفLim, Stephen S
المؤلفLo, Chun-Han
المؤلفLunevicius, Raimundas
المؤلفMalhotra, Kashish
المؤلفMaugeri, Andrea
المؤلفMediratta, Rishi P
المؤلفMeretoja, Tuomo J
المؤلفMestrovic, Tomislav
المؤلفMirza-Aghazadeh-Attari, Mohammad
المؤلفMohamed, Nouh Saad
المؤلفMokdad, Ali H
المؤلفMonasta, Lorenzo
المؤلفMoni, Mohammad Ali
المؤلفMoradi, Maryam
المؤلفMougin, Vincent
المؤلفMukoro, George Duke
المؤلفMurillo-Zamora, Efren
المؤلفMurray, Christopher J L
المؤلفNaimzada, Mukhammad David
المؤلفNajmuldeen, Hastyar Hama Rashid
المؤلفNatto, Zuhair S
المؤلفNegoi, Ionut
المؤلفNguyen, Hien Quang
المؤلفNikolouzakis, Taxiarchis Konstantinos
المؤلفOlufadewa, Isaac Iyinoluwa
المؤلفPadubidri, Jagadish Rao
المؤلفPandey, Ashok
المؤلفParikh, Romil R
المؤلفPham, Hoang Tran
المؤلفPollok, Richard Charles G
المؤلفRahimi, Mehran
المؤلفRahimi-Movaghar, Vafa
المؤلفRahman, Mosiur
المؤلفRahmani, Shayan
المؤلفRashidi, Mohammad-Mahdi
المؤلفRawaf, Salman
المؤلفRickard, Jennifer
المؤلفRouientan, Hamidreza
المؤلفRoy, Simanta
المؤلفSaddik, Basema Ahmad
المؤلفSaeed, Umar
المؤلفSaleh, Mohamed A
المؤلفSalehi, Sana
المؤلفSamy, Abdallah M
المؤلفSanabria, Juan
المؤلفSankararaman, Senthilkumar
المؤلفSchumacher, Austin E
المؤلفSenthilkumaran, Subramanian
المؤلفShah, Pritik A
المؤلفShool, Sina
المؤلفSibhat, Migbar Mekonnen
المؤلفSidamo, Negussie Boti
المؤلفSingh, Jasvinder A
المؤلفSocea, Bogdan
المؤلفSolomon, Yonatan
المؤلفSreeram, Saraswathy
المؤلفTabatabaei, Seyyed Mohammad
المؤلفTan, Ker-Kan
المؤلفTavangar, Seyed Mohammad
المؤلفTefera, Yibekal Manaye
المؤلفThomas, Nikhil Kenny
المؤلفTicoalu, Jansje Henny Vera
المؤلفTsegay, Guesh Mebrahtom
المؤلفTsegaye, Dejen
المؤلفUllah, Sana
المؤلفUsman, Abachebissa Nuru
المؤلفValizadeh, Rohollah
المؤلفVeroux, Massimiliano
المؤلفVerras, Georgios-Ioannis
المؤلفVos, Theo
المؤلفWang, Mei
المؤلفWang, Song
المؤلفWickramasinghe, Dakshitha Praneeth
المؤلفYahya, Galal
المؤلفZare, Iman
المؤلفZarrintan, Armin
المؤلفZhang, Zhi-Jiang
المؤلفDirac, M Ashworth
تاريخ الإتاحة2024-08-04T04:52:06Z
تاريخ النشر2024-07-17
اسم المنشورThe Lancet Gastroenterology & Hepatology
المعرّفhttp://dx.doi.org/10.1016/S2468-1253(24)00157-2
الرقم المعياري الدولي للكتاب24681253
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S2468125324001572
معرّف المصادر الموحدhttp://hdl.handle.net/10576/57391
الملخصBackgroundAppendicitis is a common surgical emergency that poses a large clinical and economic burden. Understanding the global burden of appendicitis is crucial for evaluating unmet needs and implementing and scaling up intervention services to reduce adverse health outcomes. This study aims to provide a comprehensive assessment of the global, regional, and national burden of appendicitis, by age and sex, from 1990 to 2021. MethodsVital registration and verbal autopsy data, the Cause of Death Ensemble model (CODEm), and demographic estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) were used to estimate cause-specific mortality rates (CSMRs) for appendicitis. Incidence data were extracted from insurance claims and inpatient discharge sources and analysed with disease modelling meta-regression, version 2.1 (DisMod-MR 2.1). Years of life lost (YLLs) were estimated by combining death counts with standard life expectancy at the age of death. Years lived with disability (YLDs) were estimated by multiplying incidence estimates by an average disease duration of 2 weeks and a disability weight for abdominal pain. YLLs and YLDs were summed to estimate disability-adjusted life-years (DALYs). FindingsIn 2021, the global age-standardised mortality rate of appendicitis was 0·358 (95% uncertainty interval [UI] 0·311–0·414) per 100 000. Mortality rates ranged from 1·01 (0·895–1·13) per 100 000 in central Latin America to 0·054 (0·0464–0·0617) per 100 000 in high-income Asia Pacific. The global age-standardised incidence rate of appendicitis in 2021 was 214 (174–274) per 100 000, corresponding to 17 million (13·8–21·6) new cases. The incidence rate was the highest in high-income Asia Pacific, at 364 (286–475) per 100 000 and the lowest in western sub-Saharan Africa, at 81·4 (63·9–109) per 100 000. The global age-standardised rates of mortality, incidence, YLLs, YLDs, and DALYs due to appendicitis decreased steadily between 1990 and 2021, with the largest reduction in mortality and YLL rates. The global annualised rate of decline in the DALY rate was greatest in children younger than the age of 10 years. Although mortality rates due to appendicitis decreased in all regions, there were large regional variations in the temporal trend in incidence. Although the global age-standardised incidence rate of appendicitis has steadily decreased between 1990 and 2021, almost half of GBD regions saw an increase of greater than 10% in their age-standardised incidence rates. InterpretationSlow but promising progress has been observed in reducing the overall burden of appendicitis in all regions. However, there are important geographical variations in appendicitis incidence and mortality, and the relationship between these measures suggests that many people still do not have access to quality health care. As the incidence of appendicitis is rising in many parts of the world, countries should prepare their health-care infrastructure for timely, high-quality diagnosis and treatment. Given the risk that improved diagnosis may counterintuitively drive apparent rising trends in incidence, these efforts should be coupled with improved data collection, which will also be crucial for understanding trends and developing targeted interventions. FundingBill and Melinda Gates Foundation.
راعي المشروعFunding was provided by the Bill & Melinda Gates Foundation (OPP1152504).
اللغةen
الموضوعGlobal Burden of Disease Study 2021
national burden of appendicitis
surgical emergency
العنوانTrends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021
النوعArticle
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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