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AuthorTalha, Muhammad
AuthorHaris Ali, Mohammad
AuthorFatima, Eeshal
AuthorNadeem, Arsalan
AuthorAhmed, Abdullah
AuthorNashwan, Abdulqadir J.
Available date2024-08-28T04:23:42Z
Publication Date2024
Publication NameAmerican Journal of Ophthalmology
ResourceScopus
ISSN29394
URIhttp://dx.doi.org/10.1016/j.ajo.2024.03.019
URIhttp://hdl.handle.net/10576/58226
AbstractPurpose: Several treatments have been in use for Demodex blepharitis, before the discovery of lotilaner, like tea tree oil and antibiotics; however, they either have irritable effects or systemic adverse effects, respectively. Lotilaner, a novel ectoparasiticide, has been proposed as a treatment for patients grappling with Demodex blepharitis. This review aims to assess the safety and efficacy of lotilaner in the treatment of Demodex blepharitis. Design: Systematic review and meta-analysis. Methods: An extensive search was conducted on PubMed, Cochrane Library, Scopus, and Google Scholar to find relevant literature till July 31, 2023 following the PRISMA guidelines. A total of 143 articles were retrieved by database searching, out of which 6 studies met the inclusion criteria and were included in the review. Four randomized controlled trials were included in the meta-analysis of mite eradication incidence. The review is registered with PROSPERO: CRD42023459997. Results: Lotilaner is effective in eradicating Demodex mites in individuals suffering from Demodex blepharitis according to RR for the intervention versus the control group of 3.55 (95% confidence interval [CI]: 2.87-4.40, P < .00001, I2 = 0%). The meta-analysis of clinically meaningful collarette score revealed the summary RR for the intervention versus the control group was 3.15 (95% CI: 2.56-3.89, P < 0.00001, I2 = 27%). In conclusion, the results of the included studies were comparable and consistent. Conclusions: Our results indicated that lotilaner is an effective, well-tolerated, and promising drug in treating patients with Demodex blepharitis. Lotilaner administration and cost-effectiveness should now be contemplated for the study population as these constituents have a vital impact on its treatment success.
SponsorFunding/Support: Open Access funding is provided by the Qatar National Library. Financial Disclosures: The authors indicate no financial support or conflicts of interest. All authors attest that they meet the current ICMJE criteria for authorship.
Languageen
PublisherElsevier
Subjectlotilaner
eye drops
application site pruritus
blepharitis
blurred vision
chalazion
confidence interval
conjunctival hyperemia
cost effectiveness analysis
demodex blepharitis
demodex blepharitis
demodicosis
demography
drug efficacy
drug safety
eye burning
eye discharge
eye pain
eye redness
human
intervention study
meta analysis
photophobia
practice guideline
prospective study
randomized controlled trial (topic)
Review
risk assessment
sample size
scoring system
skin irritation
systematic review
visual acuity
animal
blepharitis
diagnosis
drug therapy
mite
mite infestation
observational study
parasitic eye infection
parasitology
treatment outcome
Animals
Blepharitis
Eye Infections, Parasitic
Humans
Mite Infestations
Mites
Observational Studies as Topic
Ophthalmic Solutions
Treatment Outcome
TitleEfficacy and Safety of Lotilaner Ophthalmic Solution (0.25%) for the Treatment of Demodex Blepharitis: A GRADE Assessed Systematic Review and Meta-Analysis of Observational & Experimental Studies
TypeArticle Review
Pagination16-Aug
Volume Number264
dc.accessType Full Text


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