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AuthorHabib, Abdella M.
AuthorCox, James J.
AuthorOkorokov, Andrei L.
Available date2024-08-28T04:23:42Z
Publication Date2024
Publication NameTrends in Genetics
ResourceScopus
ISSN1689525
URIhttp://dx.doi.org/10.1016/j.tig.2024.04.009
URIhttp://hdl.handle.net/10576/58227
AbstractThe dark genome, the nonprotein-coding part of the genome, is replete with long noncoding RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial expression patterns, are critical gene regulators that play essential roles in health and disease. In recent years, FAAH-OUT was identified as the first lncRNA associated with an inherited human pain insensitivity disorder. Several other lncRNAs have also been studied for their contribution to chronic pain and genome-wide association studies are frequently identifying single nucleotide polymorphisms that map to lncRNAs. For a long time overlooked, lncRNAs are coming out of the dark and into the light as major players in human pain pathways and as potential targets for new RNA-based analgesic medicines.
SponsorWe gratefully acknowledge the support of our funders: Medical Research Council grant G1100340 (A.M.H. and J.J.C.); Medical Research Council grant MR/R011737/1 (J.J.C. and A.L.O.); Qatar University grants QUSD-CMED-2018/9-3 and QUCG-CMED-19/20-4 (A.M.H.); Qatar National Research Fund NPRP13S-0209-200315 (A.M.H.); and Wellcome grant 200183/Z/15/Z (J.J.C.). We thank Rayan Haroun (AstraZeneca) for critical reading of the manuscript and the patients and their families involved in the genetic studies described in this review.
Languageen
PublisherElsevier
Subjectchronic pain
dark genome
epigenetics
gene therapy
long noncoding RNA
RNA therapeutics
TitleOut of the dark: the emerging roles of lncRNAs in pain
TypeArticle Review
Pagination694-705
Issue Number8
Volume Number40
dc.accessType Full Text


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