Role of ncRNAs in the Pathogenesis of Sjögren’s Syndrome
| Author | Al-Haidose, Amal |
| Author | Hassan, Sondoss |
| Author | Elhassan, Mahmoud |
| Author | Ahmed, Eiman |
| Author | Al-Riashi, Abdulla |
| Author | Alharbi, Yazeed M. |
| Author | Ghunaim, Monther |
| Author | Alhejaili, Talal |
| Author | Abdallah, Atiyeh M. |
| Available date | 2024-08-28T04:23:43Z |
| Publication Date | 2024 |
| Publication Name | Biomedicines |
| Resource | Scopus |
| ISSN | 22279059 |
| Abstract | Sjögren’s syndrome is a multisystemic autoimmune disease that mainly affects the exocrine glands, causing dryness of the eyes and the mouth as the principal symptoms. Non-coding RNAs (ncRNAs), once regarded as genomic “junk”, are now appreciated as important molecular regulators of gene expression, not least in Sjögren’s syndrome and other autoimmune diseases. Here we review research into the causative roles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) on immunological responses, inflammation, and salivary gland epithelial cell function in Sjögren’s syndrome patients. These ncRNAs represent promising new therapeutic targets for treating the disease and possibly as biomarkers for early diagnosis. |
| Sponsor | This publication was supported by Qatar University, internal grant no. QUCP-CHS-2022-551. The findings presented herein are solely the responsibility of the authors. |
| Language | en |
| Publisher | MDPI |
| Subject | autoimmune disease non-coding RNAs RNA expression Sjögren’s syndrome |
| Type | Article Review |
| Issue Number | 7 |
| Volume Number | 12 |
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Biomedical Sciences [738 items ]