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المؤلفAl-Zoubi, Raed M.
المؤلفAbu-Hijleh, Haya
المؤلفZarour, Ahmad
المؤلفZakaria, Zain Z.
المؤلفYassin, Aksam
المؤلفAl-Ansari, Abdulla A.
المؤلفAl-Asmakh, Maha
المؤلفBawadi, Hiba
تاريخ الإتاحة2024-08-28T04:23:44Z
تاريخ النشر2024
اسم المنشورInternational Journal of Molecular Sciences
المصدرScopus
الرقم المعياري الدولي للكتاب16616596
معرّف المصادر الموحدhttp://dx.doi.org/10.3390/ijms25094895
معرّف المصادر الموحدhttp://hdl.handle.net/10576/58239
الملخصPost-traumatic stress disorder (PTSD) is a debilitating psychological condition that may develop in certain individuals following exposure to life-threatening or traumatic events. Distressing symptoms, including flashbacks, are characterized by disrupted stress responses, fear, anxiety, avoidance tendencies, and disturbances in sleep patterns. The enduring effects of PTSD can profoundly impact personal and familial relationships, as well as social, medical, and financial stability. The prevalence of PTSD varies among different populations and is influenced by the nature of the traumatic event. Recently, zebrafish have emerged as a valuable model organism in studying various conditions and disorders. Zebrafish display robust behavioral patterns that can be effectively quantified using advanced video-tracking tools. Due to their relatively simple nervous system compared to humans, zebrafish are particularly well suited for behavioral investigations. These unique characteristics make zebrafish an appealing model for exploring the underlying molecular and genetic mechanisms that govern behavior, thus offering a powerful comparative platform for gaining deeper insights into PTSD. This review article aims to provide updates on the pathophysiology of PTSD and the genetic responses associated with psychological stress. Additionally, it highlights the significance of zebrafish behavior as a valuable tool for comprehending PTSD better. By leveraging zebrafish as a model organism, researchers can potentially uncover novel therapeutic interventions for the treatment of PTSD and contribute to a more comprehensive understanding of this complex condition.
راعي المشروعThe authors declare that this study received funding from Hamad Medical Corporation. The funder was not involved in the study design; the collection, analysis, or interpretation of data; the writing of the article; or the decision to submit the article for publication.
اللغةen
الناشرMDPI
الموضوعassociative learning
post-traumatic stress disorder
stress
time-dependent sensitization
العنوانZebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool
النوعArticle Review
رقم العدد9
رقم المجلد25
dc.accessType Open Access


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