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AuthorAl-Zoubi, Raed M.
AuthorAbu-Hijleh, Haya
AuthorZarour, Ahmad
AuthorZakaria, Zain Z.
AuthorYassin, Aksam
AuthorAl-Ansari, Abdulla A.
AuthorAl-Asmakh, Maha
AuthorBawadi, Hiba
Available date2024-08-28T04:23:44Z
Publication Date2024
Publication NameInternational Journal of Molecular Sciences
ResourceScopus
ISSN16616596
URIhttp://dx.doi.org/10.3390/ijms25094895
URIhttp://hdl.handle.net/10576/58239
AbstractPost-traumatic stress disorder (PTSD) is a debilitating psychological condition that may develop in certain individuals following exposure to life-threatening or traumatic events. Distressing symptoms, including flashbacks, are characterized by disrupted stress responses, fear, anxiety, avoidance tendencies, and disturbances in sleep patterns. The enduring effects of PTSD can profoundly impact personal and familial relationships, as well as social, medical, and financial stability. The prevalence of PTSD varies among different populations and is influenced by the nature of the traumatic event. Recently, zebrafish have emerged as a valuable model organism in studying various conditions and disorders. Zebrafish display robust behavioral patterns that can be effectively quantified using advanced video-tracking tools. Due to their relatively simple nervous system compared to humans, zebrafish are particularly well suited for behavioral investigations. These unique characteristics make zebrafish an appealing model for exploring the underlying molecular and genetic mechanisms that govern behavior, thus offering a powerful comparative platform for gaining deeper insights into PTSD. This review article aims to provide updates on the pathophysiology of PTSD and the genetic responses associated with psychological stress. Additionally, it highlights the significance of zebrafish behavior as a valuable tool for comprehending PTSD better. By leveraging zebrafish as a model organism, researchers can potentially uncover novel therapeutic interventions for the treatment of PTSD and contribute to a more comprehensive understanding of this complex condition.
SponsorThe authors declare that this study received funding from Hamad Medical Corporation. The funder was not involved in the study design; the collection, analysis, or interpretation of data; the writing of the article; or the decision to submit the article for publication.
Languageen
PublisherMDPI
Subjectassociative learning
post-traumatic stress disorder
stress
time-dependent sensitization
TitleZebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool
TypeArticle Review
Issue Number9
Volume Number25
dc.accessType Open Access


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