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المؤلفFakhoury-Sayegh, Nicole
المؤلفHamdan, Aya
المؤلفLebbos, Sarah
المؤلفItani, Tarek
المؤلفTrak-Smayra, Viviane
المؤلفKhazzaka, Aline
المؤلفDagher-Hamalian, Carole
المؤلفSayegh, Lea Nicole
المؤلفMallah, May
المؤلفObeid, Omar
المؤلفSayegh, Raymond
تاريخ الإتاحة2024-09-25T10:55:08Z
تاريخ النشر2024-05-30
اسم المنشورNutrients
المعرّفhttp://dx.doi.org/10.3390/nu16111701
الاقتباسFakhoury-Sayegh, N., Hamdan, A., Lebbos, S., Itani, T., Trak-Smayra, V., Khazzaka, A., ... & Sayegh, R. (2024). Spirulina (Arthrospira platensis) Improved Nonalcoholic Fatty Liver Disease Characteristics and Microbiota and Did Not Affect Organ Fibrosis Induced by a Fructose-Enriched Diet in Wistar Male Rats. Nutrients, 16(11), 1701.
الرقم المعياري الدولي للكتاب2072-6643
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85196600201&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/59280
الملخصSpirulina (Arthrospira platensis) is reported to play a role in improving nonalcoholic fatty liver disease (NAFLD) and intestinal microbiota (IM). To study spirulina's effects in the improvement of NAFLD characteristics, IM, and pancreatic-renal lesions induced by a fructose-enriched diet, 40 Wistar healthy male rats, weighing 200-250 g, were randomly divided into four groups of 10, and each rat per group was assigned a diet of equal quantities (20 g/day) for 18 weeks. The first control group (CT) was fed a standardized diet, the second group received a 40% fructose-enriched diet (HFr), and the third (HFr-S5) and fourth groups (HFr-S10) were assigned the same diet composition as the second group but enriched with 5% and 10% spirulina, respectively. At week 18, the HFr-S10 group maintained its level of serum triglycerides and had the lowest liver fat between the groups. At the phylae and family level, and for the same period, the HFr-S10 group had the lowest increase in the Firmicutes/Bacteroidetes ratio and the Ruminococcaceae and the highest fecal alpha diversity compared to all other groups (p < 0.05). These findings suggest that at a 10% concentration, spirulina could be used in nutritional intervention to improve IM, fatty liver, metabolic, and inflammatory parameters associated with NAFLD.
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعfructose
intestinal microbiota
NAFLD
spirulina
triglycerides
العنوانSpirulina (Arthrospira platensis) Improved Nonalcoholic Fatty Liver Disease Characteristics and Microbiota and Did Not Affect Organ Fibrosis Induced by a Fructose-Enriched Diet in Wistar Male Rats
النوعArticle
رقم العدد11
رقم المجلد16
ESSN2072-6643
dc.accessType Open Access


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