Generation of human-induced pluripotent stem cells from a patient with homozygous I1234V mutation of cystic fibrosis.

Abstract

Cystic fibrosis (CF) is an inherited autosomal recessive disorder. The most predominant mutation among Qatari patients with CF is the homozygous I1234V mutation, which is more prevalent in a Bedouin tribe.1 There are no reliable models of this mutation available to study the pathogenesis of CF; therefore, discovery of an effective treatment for the disease is ongoing.