Biomedical Research Center
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Biomedical Research Center Research [766 items ]
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First report of serological, molecular detection, and characterization of human parvovirus B19 infections among sickle cell anaemia patients in Khartoum State, Sudan
( Elsevier , 2025 , Article)BackgroundPatients with haematological disorders, such as sickle cell anaemia, are at an elevated risk of transient aplastic crisis due to parvovirus B19 infection. The virus targets specific integration sites in the human ... -
S.I.: Emerging material science trends in Nanomedicine, Biosensor, Microfluidics and 3D Bioprinting technologies
( Springer , 2025 , Article)Emergent Materials has focused on applying new materials science and technologies, particularly in fast-growing areas. One such field is the biological applications of materials, i.e. Biomaterials. With this objective in ... -
Finite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations
( MDPI , 2025 , Article)Background/Objectives: For transcatheter aortic valve implantation (TAVI) therapy, a catheter-guided crimped valve is deployed into the aortic root. Valve types such as Edwards balloon-expandable valves and Medtronic ... -
Machine learning for predicting outcomes of transcatheter aortic valve implantation: A systematic review
( Elsevier , 2025 , Article)BackgroundTranscatheter aortic valve implantation (TAVI) therapy has demonstrated its clear benefits such as low invasiveness, to treat aortic stenosis. Despite associated benefits, still post-procedural complications might ... -
Rapid wall shear stress prediction for aortic aneurysms using deep learning: a fast alternative to CFD
( Springer Nature , 2025 , Article)Abstract: Aortic aneurysms pose a significant risk of rupture. Previous research has shown that areas exposed to low wall shear stress (WSS) are more prone to rupture. Therefore, precise WSS determination on the aneurysm ... -
Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Endoplasmic reticulum (ER) stress is a crucial factor in the progression of obesity-related type 2 diabetes (diabesity), contributing to skeletal muscle (SKM) dysfunction, calcium imbalance, metabolic inflexibility, and ... -
Evaluating chemiluminescent immunoassays for syphilis detection: A comparative analysis
( Elsevier , 2025 , Article)BackgroundSyphilis, caused by Treponema pallidum (TP), remains a significant global public health concern, with approximately 8 million new cases annually. Diagnosing syphilis is challenging due to its often-asymptomatic ... -
Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)GATA-3 is a master regulator of preadipocyte differentiation and function. Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and ... -
Evaluating Hospital Admission Data as Indicators of COVID-19 Severity: A National Assessment in Qatar.
( Oxford University Press , 2025 , Article)Accurately assessing SARS-CoV-2 infection severity is essential for understanding the health impact of the infection and evaluating the effectiveness of interventions. This study investigated whether SARS-CoV-2-associated ... -
Outcomes of the Qatar Transcatheter aortic valve implantation- registry (QATAVI-registry) –first report 24/7/2024
( Elsevier , 2025 , Article)BackgroundTranscatheter aortic valve implantation (TAVI) is a therapeutic modality for high-surgical-risk patients with severe aortic stenosis. This study describes the outcomes of TAVI performed in Qatar. MethodsThe Qatar ... -
Seroprevalence of influenza A H1N1 and influenza D viruses in ruminants in Qatar
( Elsevier , 2025 , Article)BackgroundInfluenza is among the most common viruses affecting humans and many animals worldwide. While influenza A (IAV) and D (IDV) viruses are associated with respiratory disease in humans and animals, respectively, ... -
Author Correction: Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance (Scientific Reports, (2019), 9, 1, (19889), 10.1038/s41598-019-56496-7)
( Nature Research , 2020 , Article)The Acknowledgements section in this Article is incomplete. "This study was funded by Qatar National Research Fund (QNRF), Grant number NPRP7-272-1-041 (MAE, KS, CG and FB). The funders had no role in study design, data ... -
Corrigendum to "Plasmid-mediated colistin resistance encoded by mcr-1 gene in Escherichia coli co-carrying blaCTX-M-15 and blaNDM-1 genes in pediatric patients in Qatar" [J Global Antimicrob Resist 22 (2020) 662-663] (Journal of Global Antimicrobial Resistance (2020) 22 (662-663), (S2213716520301740), (10.1016/j.jgar.2020.06.029))
( Elsevier , 2020 , Article)The authors regret that there was an error in the sequence types of two E. coli samples. The incorrect text previously read: Isolate CP9 belongs to ST115 and phylogenetic group A, which has been commensal and commonly ... -
Eight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women
( Nature Research , 2025 , Article)Regular aerobic exercise has a significant impact on glucose metabolism and lipid profiles, contributing to overall health improvement. However, evidence for optimal exercise duration to achieve these effects is limited. ... -
Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic Potential
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)GATA binding protein 3 (GATA3), a member of the GATA family transcription factors, is a key player in various physiological and pathological conditions. It is known for its ability to bind to the DNA sequence "GATA", which ... -
Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells
( Nature Research , 2024 , Article)Diabetes mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as ... -
Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer
( Taylor and Francis Ltd. , 2025 , Article)Objective Our study presents a novel analysis of the oncogenes and tumor suppressor proteins directly modulated by E6/E7 of high-risk HPV types 16 and 18, in colorectal cancer (CRC). Methods HCT 116 (KRAS mutant) & ... -
Metabarcoding analysis of oral microbiome during pregnancy
( Frontiers Media SA , 2024 , Article)Pregnancy is a dynamic physiological process involving significant hormonal, immune, and metabolic changes to support fetal growth and development. This study investigates the changes in salivary microbiome and biochemical ... -
GATA3: Orchestrating cellular fate through differentiation and proliferation
( Elsevier , 2025 , Article Review)Cell proliferation and differentiation are two fundamental biological processes that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). Zinc finger proteins are TFs ... -
Mindray CL-900i assay: An effective assay for hepatitis B surface antigen screening with superior specificity
( Elsevier , 2025 , Article)Objectives The chemiluminescence immunoassay automated Abbott ARCHITECT hepatitis B surface antigen (HBsAg) screening assay is globally recognized for its superior sensitivity but notably low specificity. This mandates ...
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