Biomedical Research Center: Recent submissions

Now showing items 221-240 of 771

    • Evaluation of cadmium and mercury on cardiovascular and neurological systems: Effects on humans and fish 

      Azza, Naija; Yalcin, Huseyin Cagatay ( Elsevier , 2023 , Article)
      Chemicals are at the top of public health concerns and metals have received much attention in terms of toxicological studies. Cadmium (Cd) and mercury (Hg) are among the most toxic heavy metals and are widely distributed ...

    • Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors 

      Al Thani, Najlaa A.; Hasan, Maram; Yalcin, Huseyin C. ( Springer , 2023 , Article Review)
      Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering ...

    • A New Deep Learning Method for Accurate Cardiac Heart Failure Prediction from RR Interval Measurements 

      N, Mishahira; Nair, Gayathri Geetha; Houkan, Mohammad Talal; Sadasivuni, Kishor Kumar; Geetha, Mithra; ... more authors ( IEEE , 2022 , Conference)
      cardiovascular diseases are the major cause of death worldwide. Early detection of heart failure will assist patients and medical professionals in taking better precautions to reduce risks. The objective of this study is ...

    • PCovNet: A presymptomatic COVID-19 detection framework using deep learning model using wearables data 

      Abir, Farhan Fuad; Alyafei, Khalid; Chowdhury, Muhammad E.H.; Khandakar, Amith; Ahmed, Rashid; ... more authors ( Elsevier , 2022 , Article)
      While the advanced diagnostic tools and healthcare management protocols have been struggling to contain the COVID-19 pandemic, the spread of the contagious viral pathogen before the symptom onset acted as the Achilles' ...

    • Cancer Metastasis: Dynamic Hetero-cellular Communications Between Cancer Cells and Host Tissues 

      Saliba, Jessica; El-Sabban, Maya; Shaito, Abdullah; El-Harakeh, Mohammad; Obeid, Joelle; ... more authors ( Springer International Publishing , 2023 , Book chapter)
      Metastasis is the most devastating aspect of cancer. Originally, tumor cells arise from a single clone, and then they undergo additional mutations and acquire invasive and metastatic features. These acquired mutations are ...

    • Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Hasan, Anwarul; Caceci, Thomas; ... more authors ( Springer , 2022 , Article Review)
      EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to ...

    • Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells 

      Giordo, Roberta; Cossu, Annalisa; Porcu, Maria Cristina; Cappuccinelli, Roberto; Biosa, Grazia; ... more authors ( Taylor & Francis , 2022 , Article)
      Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition ...

    • BNT162b2 antigen dose and SARS-CoV-2 omicron infection in adolescents 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ( Elsevier , 2023 , Other)
      COVID-19 vaccine antigen dose might affect protection against SARS-CoV-2 infection,1, 2 but direct evidence to quantify this effect is absent. We conducted a matched, retrospective, cohort study using a regression ...

    • Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study 

      Mestiri, Sarra; Merhi, Maysaloun; Inchakalody, Varghese P.; Taib, Nassiba; Smatti, Maria K.; ... more authors ( Frontiers Media , 2023 , Article)
      Introduction: The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Methods: ...

    • A new One Health Framework in Qatar for future emerging and re-emerging zoonotic diseases preparedness and response 

      Devendra, Bansal; Jaffrey, Shariq; Al-Emadi, Noora Abdulla; Hassan, Mahmoud; Islam, Md. Mazharul; ... more authors ( Elsevier , 2023 , Article)
      One Health is increasingly recognized as an optimal approach to address the global risk of health threats originating at the human, animal, and ecosystem interface, and their impact. Qatar has successfully practiced One ...

    • Screening and diagnostic testing protocols for HIV and Syphilis infections in health care setting in Qatar: Evaluation and recommendations 

      Nasrallah, Gheyath K.; Al-Buainain, Raniya; Younes, Nadin; Dargham, Soha R.; Al-Sadeq, Duaa W.; ... more authors ( Public Library of Science , 2023 , Article)
      Background HIV and Syphilis are common STIs, which have become a concern and burden on healthcare systems, as many infections go untreated and lead to potentially serious complications. HIV is usually diagnosed with Western ...

    • Long-term COVID-19 booster effectiveness by infection history and clinical vulnerability and immune imprinting: a retrospective population-based cohort study 

      Hiam, Chemaitelly; Ayoub, Houssein H; Tang, Patrick; Coyle, Peter; Yassine, Hadi M; ... more authors ( Elsevier , 2023 , Article)
      BackgroundLong-term effectiveness of COVID-19 mRNA boosters in populations with different previous infection histories and clinical vulnerability profiles is inadequately understood. We aimed to investigate the effectiveness ...

    • Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar 

      Mathew, Shilu; Al Khatib, Hebah A.; Al Ibrahim, Malak; Al Ansari, Khalid; Smatti, Maria K.; ... more authors ( Springer Nature , 2023 , Article)
      Background: We characterized and identified the genetic and antigenic variations of circulating rotavirus strains in comparison to used rotavirus vaccines. Methods: Rotavirus-positive samples (n = 231) were collected and ...

    • Protection against Reinfection with the Omicron BA.2.75 Subvariant 

      Chemaitelly, Hiam; Tang, Patrick; Coyle, Peter; Yassine, Hadi M.; Al-Khatib, Hebah A.; ... more authors ( Massachusetts Medical Society , 2023 , Other)
      The BA.2.75 sublineage of the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may escape neutralizing antibodies. The BA.2.75 sublineage (primarily the BA.2.75.2 subvariant) ...

    • Qatar genome: Insights on genomics from the Middle East 

      Mbarek, Hamdi; Devadoss Gandhi, Geethanjali; Selvaraj, Senthil; Al-Muftah, Wadha; Badji, Radja; ... more authors ( Wiley , 2022 , Article)
      Despite recent biomedical breakthroughs and large genomic studies growing momentum, the Middle Eastern population, home to over 400 million people, is underrepresented in the human genome variation databases. Here we ...

    • Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Pozzoli, Giacomo; Caceci, Thomas; ... more authors ( Springer , 2021 , Article Review)
      We give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are ...

    • Epac as a tractable therapeutic target 

      Hasan, Slika; Mansour, Hadi; Nasser, Suzanne A.; Shaito, Abdullah; Kobeissy, Firas; ... more authors ( Elsevier , 2023 , Article)
      In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ...

    • Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon 

      Song, Caixia; Zhou, Chao; Zhang, Junwei; Feng, Xiangyi; Cui, Xiaoshan; ... more authors ( Wiley , 2020 , Article)
      Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ...

    • Nanomedicine as a Potential Tool against Monkeypox. 

      Mohamed, Nura Adam; Zupin, Luisa; Mazi, Sarah Ismail; Al-Khatib, Hebah A; Crovella, Sergio ( MDPI , 2023 , Article Review)
      Human monkeypox is a rare viral zoonosis that was first identified in 1970; since then, this infectious disease has been marked as endemic in central and western Africa. The disease has always been considered rare and ...

    • Traumatic Brain Injury Can Affect Emotions and Behaviors 

      Shakkour, Zaynab; Habashy, Karl John; Haidar, Muhammad Ali; Nasrallah, Leila; Tabet, Maha; ... more authors ( Frontiers Media , 2023 , Article)
      Proper brain functioning is responsible for our feelings, behavior, and thinking. However, an injury to the brain can disrupt brain function, which can affect our emotions and behaviors. A traumatic brain injury (TBI) can ...