Biomedical Research Center: Recent submissions
Now showing items 281-300 of 772
-
Protective Effect of Previous SARS-CoV-2 Infection against Omicron BA.4 and BA.5 Subvariants.
( Massachusetts Medical Society , 2022 , Article)The BA.4 and BA.5 subvariants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant have shown the capacity of escaping from neutralizing antibodies.1 These subvariants had an ... -
Amniotic stem cells as a source of regenerative medicine to treat female infertility
( Springer , 2022 , Article Review)Impaired reproductive health is a worldwide problem that affects the psychological well-being of a society. Despite the technological developments to treat infertility, the global infertility rate is increasing significantly. ... -
Fecal Carriage and Molecular Characterization of Carbapenemase-Producing Enterobacterales in the Pediatric Population in Qatar
( American Society for Microbiology , 2021 , Article)Whole-genome sequencing was used to characterize carbapenemase-producing Enterobacterales (CPE) strains recovered from rectal screening swab samples obtained from children at a tertiary-care pediatric hospital in Qatar ... -
In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity
( MDPI , 2022 , Article)Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin ... -
Comparing the Metabolic Profiles Associated with Fitness Status between Insulin-Sensitive and Insulin-Resistant Non-Obese Individuals
( MDPI , 2022 , Article)(1) Background: Young non-obese insulin-resistant (IR) individuals could be at risk of developing metabolic diseases including type 2 diabetes mellitus. The protective effect of physical activity in this apparently healthy ... -
Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells
( Frontiers Media , 2022 , Article)Elaeagnus angustifolia (EA) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of human oral and ... -
Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo.
( MDPI , 2022 , Article)Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ... -
Microbiome engineering to combat antimicrobial resistance and upsurge productivity of food animals: a systematic review
( CSIRO Publishing , 2022 , Article)Extensive antimicrobial usage in animal farming plays a prominent role in the antimicrobial resistance (AMR) crisis and is repeatedly highlighted as an area needing development under the ‘One Health’ approach. Alternative ... -
Lipid-lowering therapies for atherosclerosis: Statins, fibrates, ezetimibe and pcsk9 monoclonal antibodies
( Bentham Science Publishers , 2021 , Article Review)Cardiovascular disease (CVD) remains the primary cause of global morbidity and mortality. CVD includes various life-threatening conditions such as myocardial infarction, stroke and peripheral arterial diseases. In this ... -
COVID-19 Disease Severity in Persons Infected with Omicron BA.1 and BA.2 Sublineages and Association with Vaccination Status
( American Medical Association , 2022 , Article)Infection with the SARS-CoV-2 Omicron variant is associated with less severe disease compared with the Delta variant.1-3 Two main Omicron sublineages—BA.1 and BA.2—have variable geographic distribution. In Qatar, BA.1 was ... -
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
( Elsevier , 2022 , Article Review)Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating ... -
Do preexisting antibodies against seasonal coronaviruses have a protective role against SARS-CoV-2 infections and impact on COVID-19 severity?
( Elsevier , 2022 , Article)Because of the emergence of coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), many questions remain unresolved regarding the abundance of cross-reactivity ... -
Eco-friendly highly efficient BN/rGO/TiO2 nanocomposite visible-light photocatalyst for phenol mineralization
( Springer , 2021 , Article)Boron nitride (BN) and reduced graphene oxide (rGO) of different loadings were composited with commercial P25 TiO2 (Ti) through the hydrothermal method. The as-prepared nanocomposites were characterized using various ... -
Synthesis and Optimization of a Highly Stable and Efficient BN/TiO2 Nanocomposite for Phenol Degradation: A Photocatalytic, Mechanistic and Environmental Impact Study
( Wiley , 2021 , Article)Different BN/TiO2 nanocomposites were prepared hydrothermally, and their ratio was optimized to get the best photocatalytic performance towards phenol degradation. They were characterized by x-ray photoelectron spectroscopy, ... -
Introduction and expansion of the SARS-CoV-2 B.1.1.7 variant and reinfections in Qatar: A nationally representative cohort study
( Public Library of Science , 2021 , Article)Background The epidemiology of the SARS-CoV-2 B.1.1.7 (or Alpha) variant is insufficiently understood. This study’s objective was to describe the introduction and expansion of this variant in Qatar and to estimate the ... -
Assessing the performance of a serological point-of-care test in measuring detectable antibodies against SARS-CoV-2
( Public Library of Science , 2022 , Article)This study investigated the performance of a rapid point-of-care antibody test, the BioMedomics COVID-19 IgM/IgG Rapid Test, in comparison with a high-quality, validated, laboratory-based platform, the Roche Elecsys ... -
Reporting of RT-PCR cycle threshold (Ct) values during the first wave of COVID-19 in Qatar improved result interpretation in clinical and public health settings
( Microbiology Society , 2022 , Article)Introduction. The cycle threshold (Ct) value in real-time PCR (RT-PCR) is where a target-specific amplification signal becomes detectable and can infer viral load, risk of transmission and recovery. Use of Ct values in ... -
COVID-19 risk score as a public health tool to guide targeted testing: A demonstration study in Qatar
( Public Library of Science , 2022 , Article)We developed a Coronavirus Disease 2019 (COVID-19) risk score to guide targeted RTPCR testing in Qatar. The Qatar national COVID-19 testing database, encompassing a total of 2,688,232 RT-PCR tests conducted between February ... -
Effectiveness of mRNA booster doses against the omicron variant
( Elsevier , 2022 , Article)Since its emergence in November, 2021, the omicron (B.1.1.529) variant of SARS-CoV-2 has rapidly spread and quickly overtaken the delta (B.1.617.2) variant as the most common cause of infection.1 Due to numerous spike ... -
Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model
( American Chemical Society , 2022 , Article)Background: nanotechnology is one of the fastest-growing areas, and it is expected to have a substantial economic and social impact in the upcoming years. Gold particles (AuNPs) offer an opportunity for wide-ranging ...
