Biomedical Research Center: Recent submissions

Now showing items 461-480 of 735

    • Advances in Cardiovascular Biomarker Discovery. 

      Ghantous, Crystal M; Kamareddine, Layla; Farhat, Rima; Zouein, Fouad A; Mondello, Stefania; ... more authors ( MDPI , 2020 , Article Review)
      Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ...

    • Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar 

      Soha R., Dargham; Al-Sadeq, Duaa W.; Yassine, Hadi M.; Ahmed, Muna; Kunhipurayil, Hasna; ... more authors ( Elsevier , 2020 , Article)
      ObjectiveTo estimate the age- and nationality-specific West Nile virus (WNV) seroprevalence in select Middle East and North Africa (MENA) populations residing in Qatar. MethodsSera were collected from male blood donors ...

    • Assessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes Reveals Unique Profiles Associated With Different Sport Disciplines 

      Sohail, Muhammad U.; Al-Mansoori, Layla; Al-Jaber, Hend; Georgakopoulos, Costas; Donati, Francesco; ... more authors ( Frontiers Media , 2020 , Article)
      © Copyright © 2020 Sohail, Al-Mansoori, Al-Jaber, Georgakopoulos, Donati, Botrè, Sellami and Elrayess. Objectives: Circulating cytokines and oxidative stress markers vary in response to different exercise regimens. This ...

    • Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis. 

      Smatti, Maria K; Al-Sarraj, Yasser A; Albagha, Omar; Yassine, Hadi M ( Frontiers Media , 2020 , Article)
      Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly due to host ...

    • Within-Host Diversity of SARS-CoV-2 in COVID-19 Patients With Variable Disease Severities. 

      Al Khatib, Hebah A; Benslimane, Fatiha M; Elbashir, Israa E; Coyle, Peter V; Al Maslamani, Muna A; ... more authors ( Frontiers Media , 2020 , Article)
      The ongoing pandemic of SARS-COV-2 has already infected more than eight million people worldwide. The majority of COVID-19 patients either are asymptomatic or have mild symptoms. Yet, about 15% of the cases experience ...

    • Immune Modulatory Effects of Vitamin D on Viral Infections. 

      Siddiqui, Maheen; Manansala, Judhell S; Abdulrahman, Hana A; Nasrallah, Gheyath K; Smatti, Maria K; ... more authors ( MDPI , 2020 , Article)
      Viral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the ...

    • Seasonality of Respiratory Viral Infections: Will COVID-19 Follow Suit? 

      Audi, Amani; AlIbrahim, Malak; Kaddoura, Malak; Hijazi, Ghina; Yassine, Hadi M; ... more authors ( Frontiers Media , 2020 , Article Review)
      Respiratory viruses, including coronaviruses, are known to have a high incidence of infection during winter, especially in temperate regions. Dry and cold conditions during winter are the major drivers for increased ...

    • Rapid Antibody-Based COVID-19 Mass Surveillance: Relevance, Challenges, and Prospects in a Pandemic and Post-Pandemic World. 

      Augustine, Robin; Das, Suvarthi; Hasan, Anwarul; S, Abhilash; Abdul Salam, Shaheen; ... more authors ( MDPI , 2020 , Article Review)
      The aggressive outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as COVID-19 (coronavirus disease-2019) pandemic demands rapid and simplified testing tools for its effective management. Increased ...

    • Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies 

      Hadi M., Yassine; Al-Jighefee, Hadeel; Al-Sadeq, Duaa W.; Dargham, Soha R.; Younes, Salma N.; ... more authors ( Elsevier , 2020 , Article)
      ObjectivesTo evaluate and compare the performances of five commercial ELISA assays (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG. Methods70 negative control samples (collected before the ...

    • Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids. 

      Diboun, Ilhame; Al-Mansoori, Layla; Al-Jaber, Hend; Albagha, Omar; Elrayess, Mohamed A ( Endocrine Society , 2020 , Article)
      The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular mediators ...

    • Growth factor loaded in situ photocrosslinkable poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/gelatin methacryloyl hybrid patch for diabetic wound healing 

      Augustine, Robin; Hasan, Anwarul; Dalvi, Yogesh B.; Rehman, Syed Raza Ur; Varghese, Ruby; ... more authors ( Elsevier , 2021 , Article)
      © 2020 The Authors Management of chronic diabetic ulcers remains as a major challenge in healthcare which requires extensive multidisciplinary approaches to ensure wound protection, management of excess wound exudates and ...

    • Application of a flow-induced stress wave and investigation of associated injuries on cell monolayers using a parallel plate flow chamber 

      Shurbaji, Samar; Al-Ruweidi, Mahmoud Khatib A.A.; Ali, Fatma Hassan; Benslimane, Fatiha M.; Yalcin, Huseyin C. ( MDPI , 2020 , Article)
      © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications ...

    • Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model 

      Da'as, Sahar I.; Yalcin, Huseyin C.; Nasrallah, Gheyath K.; Mohamed, Iman A.; Nomikos, Michail; ... more authors ( Wiley , 2020 , Article)
      © 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ...

    • A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway 

      Sartelli, Massimo; Kluger, Yoram; Ansaloni, Luca; Carlet, Jean; Brink, Adrian; ... more authors ( Mary Ann Liebert Inc. , 2017 , Article)
      This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use ...

    • Heart function and hemodynamic analysis for zebrafish embryos 

      Yalcin, Huseyin C.; Amindari, Armin; Butcher, Jonathan T.; Althani, Asma; Yacoub, Magdi ( John Wiley and Sons Inc. , 2017 , Article Review)
      The Zebrafish has emerged to become a powerful vertebrate animal model for cardiovascular research in recent years. Its advantages include easy genetic manipulation, transparency, small size, low cost, and the ability to ...

    • Calreticulin regulates Src kinase in osteogenic differentiation from embryonic stem cells 

      Zahra, Alvandi; Al-Mansoori, Layla J.R; Opas, Michal ( Elsevier , 2020 , Article)
      Calreticulin, the major Ca2+ buffer of the endoplasmic reticulum plays an important role in the choice of fate by embryonic stem cells. Using the embryoid body method of organogenesis, we showed impaired osteogenesis in ...

    • Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery. 

      Diboun, Ilhame; Ramanjaneya, Manjunath; Majeed, Yasser; Ahmed, Lina; Bashir, Mohammed; ... more authors ( BMC , 2020 , Article)
      Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood samples collected ...

    • Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis. 

      López-Ozuna, Vanessa M; Gupta, Ishita; Kiow, Ryan Liu Chen; Matanes, Emad; Kheraldine, Hadeel; ... more authors ( MDPI , 2020 , Article)
      Water-pipe smoking (WPS) is becoming the most popular form of tobacco use among the youth, especially in the Middle East, replacing cigarettes rapidly and becoming a major risk of tobacco addiction worldwide. Smoke from ...

    • Co-incidence of Human Papillomaviruses and Epstein-Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria. 

      Gupta, Ishita; Ghabreau, Lina; Al-Thawadi, Hamda; Yasmeen, Amber; Vranic, Semir; ... more authors ( Frontiers Media , 2020 , Article)
      High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the ...

    • Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells 

      Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; ... more authors ( MDPI , 2020 , Article)
      Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ...