Prevalence of hypodontia and other developmental dental anomalies in children with or without molar incisor hypomineralisation
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Date
2025-04-30Author
Hani, NazzalRodd, Helen D.
Alrashed, Hoor N.
Bonifacio, Clarissa Calil
Choe, Ruth Wei
Crombie, Felicity
El Shafei, Jumana
El Shahawy, Osama
Al Sheeb, Muneera
Foláyan, Moréniké Oluwátóyìn
Arowolo, Olaniyi
Gambetta-Tessini, Karla
de Vries, Aniek
Goyal, Ashima
Gupta, Arpit
Hasmun, Noren
Hussein, Iyad
Issa, Ahmad I.
Jundi, Suhad
Abedalhaleem, Eman Bassam
Kowash, Mawlood
Alshamsi, Aysha
Salami, Anas
Manton, David J.
Muñoz-Sandoval, Cecilia
Narasimhan, Srinivasan
Omar, Samah
Parekh, Susan
Drysdale, David
Popoola, Bamidele O.
Shields, Stephanie
Silva, Mihiri J.
Taylor, Greig
Yang, Naomi Qiyue
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ObjectivesTo investigate whether hypodontia and other developmental dental anomalies were more common in children with MIH than their unaffected peers, and to determine if sex or geographical location had any effect on hypodontia prevalence. MethodsThis analytical cross-sectional study was conducted in specialist paediatric dentistry clinics across 14 countries, categorised into six geographical regions. A total of 1279 children (aged 6 - 17 years) underwent a clinical examination and were allocated to the MIH (n = 649) or comparison group (n = 630). A validated MIH index was used to record the presence/extent of any hypomineralisation and a standardised approach was used to establish the clinical and/or radiographic presence of ten developmental dental anomalies. ResultsFour anomalies were significantly more prevalent in participants with MIH than those without this condition: hypodontia (p = 0.047), dens invaginatus (p = 0.004), dens evaginatus (p < 0.001) and microdont maxillary lateral incisors (p = 0.01). Additionally, the adjusted odds of hypodontia were 1.49 times higher in children with MIH compared to those without MIH. There was considerable disparity between geographic locations with the highest prevalence of hypodontia in participants from the Western Pacific region (11.21 %) and the lowest (2.92 %) in the Americas. No statistically significant association was found between sex (male vs. female) and hypodontia (p = 0.839). ConclusionsAccepting that the study group may not be representative of the wider population, the findings still have important clinical relevance. Furthermore, they lend support to the concept of shared genetic and epigenetic influence in the aetiology of MIH and other developmental dental disorders.
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- Dental Medicine Research [378 items ]