The association and LINKGAGE of various retroviruses ANDITS progression towards Neurodegeneration
Date
2018-03-01Author
Mathew, ShiluMUHAMMAD, FAHEEM
HAROON, HAMED
SUGANTHY, NATARAJAN
WAQAS, IQBAL
GOVINDA, ARJUNAN
KANEEZ, FATIMA
ISHTIAQ, QADRI
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ABSTRACT
Effective prevention and treatment of infectious diseases has played an enormous role for the healthy outlook of human
being. However at the same time, chronic ailments such as neurodegenerative diseases are on rapid rise, afflicting
several hundred million individuals worldwide. The commonly known and studied diseases include Alzheimer’s disease,
Parkinson’s, Huntington’s, Frontal Temporal Dementia, Multiple Sclerosis, Cerebral Palsy and Amyotrophic Lateral
Sclerosis. In this review article we highlight the importance of viruses in the progression of various neurodegenerative
diseases and cerebral palsy. The viruses included retroviruses, HSV-1, HSV-2, VZV, EBV, CMV, HHV-6, HHV-7, and
HHV-8, members of the retroviruses, endogenous retrotranspsons and enteroviruses family. Viral gene and their
interplay with the cellular machinery are also highlighted. The pathways that are perturbed by the viral infections are
discussed and strategy is defined to combat such infections. Although there is no direct evidence that neurodegenerative
diseases are caused by viruses, aberrant inflammatory reactions triggered by viral infections are critical determinant of
neurodegeneration. This is predominantly preferential in individual with genetic mutations or epigenetic divergences that
modulate the immune response or susceptibility to viral diseases. More specifically, we amalgamate concept that
inflammation resulting from viral infections can initiate and propagate chronic neuronal dysfunction. In summary the
therapeutic approaches to target immunological pathways of disease are presented to lower the incidence of
neurodegenerative disorders and to create therapeutic opportunities for neuroprotection.
Keywords: Neurodegenerative, Viruses, Therapeutic, Pathway
DOI/handle
http://hdl.handle.net/10576/6442Collections
- Biomedical Research Center Research [709 items ]