Spotlight commentary: Changes in pharmacokinetics following significant weight loss

Abstract

Obesity is associated with detrimental metabolic, mechanical and psy-chological outcomes, leading to diminished qualify of life and reducedlifespan. Whilst lifestyle modifications, including diet and physicalactivity, remain essential for managing obesity management, manypatients with obesity require additional interventions for effectivetreatment. These include anti-obesity medicines (e.g., GLP-1 receptoragonists) and/or bariatric surgery.