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المؤلفSmatti, Maria K.
المؤلفAl-Sadeq, Duaa W.
المؤلفAli, Nadima H.
المؤلفPintus, Gianfranco
المؤلفAbou-Saleh, Haissam
المؤلفNasrallah, Gheyath K.
تاريخ الإتاحة2018-06-27T07:55:38Z
تاريخ النشر2018-06-13
اسم المنشورFrontiers in Oncology
المعرّفhttp://dx.doi.org/10.3389/fonc.2018.00211
الاقتباسSmatti MK, Al-Sadeq DW, Ali NH, Pintus G, Abou-Saleh H and Nasrallah GK (2018) Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update. Front. Oncol. 8:211. doi: 10.3389/fonc.2018.00211
الرقم المعياري الدولي للكتاب2234-943X
المعرّفArticle number: 211
معرّف المصادر الموحدhttp://hdl.handle.net/10576/6762
معرّف المصادر الموحدhttp://dx.doi.org/10.3389/fonc.2018.00211
الملخصThe Epstein–Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide and has been linked to several malignancies including PTLDs, which are one of the most common malignancies following transplantation. Among all the EBV genes, most of the recent investigations focused on studying the LMP-1 oncogene because of its high degree of polymorphism and association with tumorigenic activity. There are two main EBV genotypes, Type 1 and 2, distinguished by the differences in the EBNA-2 gene. Further sub genotyping can be characterized by analyzing the LMP-1 gene variation. The virus primarily transmits through oral secretions and persists as a latent infection in human B-cells. However, it can be transmitted through organ transplantations and blood transfusions. In addition, symptoms of EBV infection are not distinguishable from other viral infections, and therefore, it remains questionable whether there is a need to screen for EBV prior to blood transfusion. Although the process of leukoreduction decreases the viral copies present in the leukocytes, it does not eliminate the risk of EBV transmission through blood products. Here, we provide a review of the EBV epidemiology and the genetic variability of the oncogene LMP-1. Then, we underscore the findings of recent EBV seroprevalence and viremia studies among blood donors as a highly prevalent transfusion transmissible oncovirus
اللغةen
الناشرFrontiers Medi
الموضوعblood donors
epstein–Barr virus
LMP-1 oncogene
seroprevalence
transfusion
viremia
العنوانEpstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
النوعArticle Review
الصفحات1-16
رقم المجلد8
dc.accessType Open Access


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