Biomedical Research Center
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Biomedical Research Center Research [776 items ]
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Efficacy and safety of daratumumab for the treatment of refractory/relapsed multiple myeloma. A systematic review of meta-analyses
( SAGE Publications Ltd , 2025 , Article Review)Introduction: Several meta-analyses (MAs) of the efficacy and safety of daratumumab in refractory/relapsed multiple myeloma (RRMM) exist. They include different types of populations, Daratumumab regimens, and outcomes. ... -
Unraveling the proteomic signatures of coronary artery disease and hypercholesterolemia.
( The Association of Basic Medical Sciences , 2024 , Article)Atherosclerosis, a leading cause of coronary artery disease (CAD), is heavily influenced by hypercholesterolemia (HC). Proteomics research has shown promise in identifying biological markers for CAD diagnosis and prognosis. ... -
Evaluating the Effects of BSA-Coated Gold Nanorods on Cell Migration Potential and Inflammatory Mediators in Human Dermal Fibroblasts
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Albumin-coated gold nanoparticles display potential biomedical applications, including cancer research, infection treatment, and wound healing; however, elucidating their interaction with normal cells remains an area with ... -
Enhancing Influenza Detection through Integrative Machine Learning and Nasopharyngeal Metabolomic Profiling: A Comprehensive Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background/Objectives: Nasal and nasopharyngeal swabs are commonly used for detecting respiratory viruses, including influenza, which significantly alters host cell metabolites. This study aimed to develop a machine learning ... -
Seroprevalence and detection of Human herpesvirus-8 (HHV-8) among healthy blood donors residing in Qatar
( Elsevier , 2024 , Article)BackgroundHuman herpesvirus 8 (HHV-8) is a critical causative agent behind Kaposi sarcoma (KS), an oncogenic disease with profound consequences in immunocompromised individuals. Studies suggested HHV-8 seroprevalence in ... -
Combining Gram stain and 16S qPCR improved diagnostic accuracy for suspected pneumonia and could become a new metric in the rapid diagnosis of lower respiratory tract infections
( Microbiology Society , 2024 , Article)Introduction. The frequency of multidrug-resistant organisms (MDROs) in hospitals and the risk of delaying effective treatment result in the culture of respiratory secretions for nearly all patients with suspected pneumonia. ... -
Beyond nutrition: The emerging therapeutic potential landscape of breast milk-derived extracellular vesicles
( Elsevier , 2025 , Article)Breastfeeding is widely recognized for its essential nutritional benefits and broader biological impacts. Beyond providing infants with a balanced mix of vitamins, proteins, and fats critical for growth and development, ... -
Understanding Heritable Variation Among Hosts in Infectious Diseases Through the Lens of Twin Studies
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article Review)Genetic factors have been hypothesized to contribute to the heterogeneity in the response to infectious diseases (IDs). The classical twin design provides a powerful tool to estimate the role of genetic contributions to ... -
The influence of circadian rhythm disruption during Ramadan on metabolic responses to physical activity: a pilot study
( Frontiers Media SA , 2025 , Article)Background: Circadian rhythms and sleep patterns are important regulators of metabolic health. During Ramadan intermittent fasting (RIF), the sleep–wake cycles are often disrupted, which can affect physical activity (PA) ... -
Chromosome-level reference genome assembly of the gyrfalcon (Falco rusticolus) and population genomics offer insights into the falcon population in Mongolia
( Nature Research , 2025 , Article)The taxonomic classification of a falcon population found in the Mongolian Altai region in Asia has been heavily debated for two centuries and previous studies have been inconclusive, hindering a more informed conservation ... -
First report of serological, molecular detection, and characterization of human parvovirus B19 infections among sickle cell anaemia patients in Khartoum State, Sudan
( Elsevier , 2025 , Article)BackgroundPatients with haematological disorders, such as sickle cell anaemia, are at an elevated risk of transient aplastic crisis due to parvovirus B19 infection. The virus targets specific integration sites in the human ... -
S.I.: Emerging material science trends in Nanomedicine, Biosensor, Microfluidics and 3D Bioprinting technologies
( Springer , 2025 , Article)Emergent Materials has focused on applying new materials science and technologies, particularly in fast-growing areas. One such field is the biological applications of materials, i.e. Biomaterials. With this objective in ... -
Finite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations
( MDPI , 2025 , Article)Background/Objectives: For transcatheter aortic valve implantation (TAVI) therapy, a catheter-guided crimped valve is deployed into the aortic root. Valve types such as Edwards balloon-expandable valves and Medtronic ... -
Machine learning for predicting outcomes of transcatheter aortic valve implantation: A systematic review
( Elsevier , 2025 , Article)BackgroundTranscatheter aortic valve implantation (TAVI) therapy has demonstrated its clear benefits such as low invasiveness, to treat aortic stenosis. Despite associated benefits, still post-procedural complications might ... -
Rapid wall shear stress prediction for aortic aneurysms using deep learning: a fast alternative to CFD
( Springer Nature , 2025 , Article)Abstract: Aortic aneurysms pose a significant risk of rupture. Previous research has shown that areas exposed to low wall shear stress (WSS) are more prone to rupture. Therefore, precise WSS determination on the aneurysm ... -
Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Endoplasmic reticulum (ER) stress is a crucial factor in the progression of obesity-related type 2 diabetes (diabesity), contributing to skeletal muscle (SKM) dysfunction, calcium imbalance, metabolic inflexibility, and ... -
Evaluating chemiluminescent immunoassays for syphilis detection: A comparative analysis
( Elsevier , 2025 , Article)BackgroundSyphilis, caused by Treponema pallidum (TP), remains a significant global public health concern, with approximately 8 million new cases annually. Diagnosing syphilis is challenging due to its often-asymptomatic ... -
Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)GATA-3 is a master regulator of preadipocyte differentiation and function. Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and ... -
Evaluating Hospital Admission Data as Indicators of COVID-19 Severity: A National Assessment in Qatar.
( Oxford University Press , 2025 , Article)Accurately assessing SARS-CoV-2 infection severity is essential for understanding the health impact of the infection and evaluating the effectiveness of interventions. This study investigated whether SARS-CoV-2-associated ... -
Outcomes of the Qatar Transcatheter aortic valve implantation- registry (QATAVI-registry) –first report 24/7/2024
( Elsevier , 2025 , Article)BackgroundTranscatheter aortic valve implantation (TAVI) is a therapeutic modality for high-surgical-risk patients with severe aortic stenosis. This study describes the outcomes of TAVI performed in Qatar. MethodsThe Qatar ...
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