Browsing by Author "Abdulla, Sara A."
Now showing items 1-7 of 7
-
Blood Proteomics Analysis Reveals Potential Biomarkers and Convergent Dysregulated Pathways in Autism Spectrum Disorder: A Pilot Study
Mesleh, Areej; Ehtewish, Hanan; de la Fuente, Alberto; Al-shamari, Hawra; Ghazal, Iman; Al-Faraj, Fatema; Al-Shaban, Fouad; Abdesselem, Houari B.; Emara, Mohamed; Alajez, Nehad M.; Arredouani, Abdelilah; Decock, Julie; Albagha, Omar; Stanton, Lawrence W.; Abdulla, Sara A.; El-Agnaf, Omar M.A.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Autism spectrum disorder (ASD) is an umbrella term that encompasses several disabling neurodevelopmental conditions. These conditions are characterized by impaired manifestation in social and communication skills with ... -
Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs
Salloum-Asfar, Salam; Abdulla, Sara A.; Taha, Rowaida Z.; Thompson, I. Richard; Emara, Mohamed M. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Somatic cells are reprogrammed with reprogramming factors to generate induced pluripotent stem cells (iPSCs), offering a promising future for disease modeling and treatment by overcoming the limitations of embryonic stem ... -
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
Gupta, Vijay; Salim, Safa; Hmila, Issam; Vaikath, Nishant N.; Sudhakaran, Indulekha P.; Ghanem, Simona S.; Majbour, Nour K.; Abdulla, Sara A.; Emara, Mohamed M.; Abdesselem, Houari B.; Lukacsovich, Tamas; Erskine, Daniel; El-Agnaf, Omar M.A.... more authors ... less authors ( Springer Nature , 2020 , Article)Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches ... -
High-throughput autoantibody screening identifies differentially abundant autoantibodies in autism spectrum disorder
Mesleh, Areej; Ehtewish, Hanan; Lennard, Katie; Abdesselem, Houari B.; Al-Shaban, Fouad; Decock, Julie; Alajez, Nehad M.; Arredouani, Abdelilah; Emara, Mohamed M.; Albagha, Omar; Stanton, Lawrence W.; Abdulla, Sara A.; Blackburnand, Jonathan M.; El-Agnaf, Omar M.A.... more authors ... less authors ( Frontiers Media SA , 2023 , Article)Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by defects in two core domains, social/communication skills and restricted/repetitive behaviors or interests. There is no approved ... -
Hyperosmotic Stress Induces a Specific Pattern for Stress Granule Formation in Human-Induced Pluripotent Stem Cells
Salloum-Asfar, Salam; Engelke, Rudolf; Mousa, Hanaa; Goswami, Neha; Thompson, I. Richard; Palangi, Freshteh; Kamal, Kamal; Al-Noubi, Muna N.; Schmidt, Frank; Abdulla, Sara A.; Emara, Mohamed M.... more authors ... less authors ( Hindawi , 2021 , Article)Stress granules (SGs) are assemblies of selective messenger RNAs (mRNAs), translation factors, and RNA-binding proteins in small untranslated messenger ribonucleoprotein (mRNP) complexes in the cytoplasm. Evidence indicates ... -
Identification of potential transcription factors that enhance human iPSC generation
Swaidan, Nuha T.; Salloum-Asfar, Salam; Palangi, Freshteh; Errafii, Khaoula; Soliman, Nada H.; Aboughalia, Ahmed T.; Wali, Abdul Haseeb S.; Abdulla, Sara A.; Emara, Mohamed M.... more authors ... less authors ( Springer Nature , 2020 , Article)Although many factors have been identified and used to enhance the iPSC reprogramming process, its efficiency remains quite low. In addition, reprogramming efficacy has been evidenced to be affected by disease mutations ... -
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
Ardah, Mustafa T; Ghanem, Simona S; Abdulla, Sara A; Lv, Guohua; Emara, Mohamed M; Paleologou, Katerina E; Vaikath, Nishant N; Lu, Jia-Hong; Li, Min; Vekrellis, Konstantinos; Eliezer, David; El-Agnaf, Omar M A... more authors ... less authors ( BMC , 2020 , Article)Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia ...