Browsing by Author "Thillaiappan, Nagendra Babu"

Now showing items 1-4 of 4

    • IP3 receptors and their intimate liaisons 

      Peace, Atakpa-Adaji; Thillaiappan, Nagendra Babu; Taylor, Colin W ( Elsevier , 2020 , Article Review)
      Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels. They allow cell-surface receptors that stimulate IP3 formation to evoke rapid Ca2+ release from the endoplasmic reticulum (ER). IP3Rs initiate ...

    • KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals 

      Thillaiappan, Nagendra Babu; Smith, Holly A.; Atakpa-Adaji, Peace; Taylor, Colin W. ( Nature Research , 2021 , Article)
      Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile ...

    • The store-operated Ca entry complex comprises a small cluster of STIM1 associated with one Orai1 channel. 

      Shen, Yihan; Thillaiappan, Nagendra Babu; Taylor, Colin W ( National Academy of Sciences , 2021 , Article)
      Increases in cytosolic Ca concentration regulate diverse cellular activities and are usually evoked by opening of Ca channels in intracellular Ca stores and the plasma membrane (PM). For the many signals that evoke formation ...

    • Vitamin D and Its Potential Interplay With Pain Signaling Pathways 

      Habib, Abdella M; Nagi, Karim; Thillaiappan, Nagendra Babu; Akhtar, Saghir; vijayakumar, sukumaran ( Frontiers Media , 2020 , Article Review)
      About 50 million of the U.S. adult population suffer from chronic pain. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~20% of the sufferers ...