Browsing by Author "Theodoridou, Maria"
Now showing items 1-4 of 4
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Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket
Thanassoulas, Angelos; Theodoridou, Maria; Barrak, Laila; Riguene, Emna; Alyaarabi, Tamader; Elrayess, Mohamed A.; Lai, F. Anthony; Nomikos, Michail... more authors ... less authors ( MDPI , 2023 , Article)Calmodulin (CaM) is a small, multifunctional calcium (Ca2+)-binding sensor that binds and regulates the open probability of cardiac ryanodine receptor 2 (RyR2) at both low and high cytosolic Ca2+ concentrations. Recent ... -
Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C
Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Theodoridou, Maria; Buntwal, Luke; Sideratou, Zili; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2017 , Article)Sperm-specific Phospholipase C zeta (PLCζ) is widely considered to be the sole, physiological stimulus responsible for the generation of Ca2+ oscillations that induce egg activation and early embryo development during ... -
Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function
Nomikos, Michail; Thanassoulas, Angelos; Beck, Konrad; Theodoridou, Maria; Kew, Jasmine; Kashir, Junaid; Calver, Brian L.; Matthews , Emily; Rizkallah, Pierre; Sideratou, Zili; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Blackwell Publishing Ltd , 2016 , Article)Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with ... -
The Relationship between Changes in MYBPC3 Single-Nucleotide Polymorphism-Associated Metabolites and Elite Athletes’ Adaptive Cardiac Function
Riguene, Emna; Theodoridou, Maria; Barrak, Laila; Elrayess, Mohamed A.; Nomikos, Michail ( MDPI , 2023 , Article Review)Athletic performance is a multifactorial trait influenced by a complex interaction of environmental and genetic factors. Over the last decades, understanding and improving elite athletes’ endurance and performance has ...