Browsing by Author "Sari, Youssef"
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Monoamine oxidase inhibitors extracted from tobacco smoke as neuroprotective factors for potential treatment of Parkinson’s disease
Sari, Youssef; Khalil, Ashraf ( Bentham Science Publishers B.V. , 2015 , Article)Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of mainly the nigrostriatal dopaminergic neurons, which leads to motor dysfunction. Although, most of the drugs are currently used for ... -
SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
Shalaby, Raed; Petzer, Jacobus P.; Petzer, Anél; Ashraf, Usman M.; Atari, Ealla; Alasmari, Fawaz; Kumarasamy, Sivarajan; Sari, Youssef; Khalil, Ashraf... more authors ... less authors ( Taylor and Francis Ltd. , 2019 , Article)The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. ... -
Targeting dopaminergic system for treating nicotine dependence
Abuhamdah, Sawsan; Khalil, Ashraf; Sari, Youssef ( Bentham Science Publishers B.V. , 2016 , Article)Background: Smoking is the world's leading cause of preventable death among populations. Cigarette smoking increases the risk of numerous health problems, including heart diseases, stroke, atherosclerosis and many types ...