Browsing by Author "Zibara, Kazem"
Now showing items 1-14 of 14
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Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model
Kobeissy, Firas; Shaito, Abdullah; Kaplan, Abdullah; Baki, Lama; Hayek, Hassan; Dagher-Hamalian, Carole; Nehme, Ali; Ghali, Rana; Abidi, Emna; Husari, Ahmad; Zeidan, Asad; Zouein, Fouad A.; Zibara, Kazem... more authors ... less authors ( Hindawi Limited , 2017 , Article)Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial ... -
Combination of Angiotensin (1-7) Agonists and Convalescent Plasma as a New Strategy to Overcome Angiotensin Converting Enzyme 2 (ACE2) Inhibition for the Treatment of COVID-19
Issa, Hawraa; Eid, Ali H.; Berry, Bassam; Takhviji, Vahideh; Khosravi, Abbas; Mantash, Sarah; Nehme, Rawan; Hallal, Rawan; Karaki, Hussein; Dhayni, Kawthar; Faour, Wissam H.; Kobeissy, Firas; Nehme, Ali; Zibara, Kazem... more authors ... less authors ( Frontiers , 2021 , Article)Coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the most concerning health problem worldwide. SARS-CoV-2 infects cells by binding to ... -
The effect of clopidogrel and aspirin on the severity of traumatic brain injury in a rat model
Firas, Kobeissy; Mallah, Khalil; Zibara, Kazem; Dakroub, Fatima; Dalloul, Zeinab; Nasser, Mohammad; Nasrallah, Leila; Mallah, Zahraa; El-Achkar, Ghewa A.; Ramadan, Naify; Mohamed, Wael; Mondello, Stefania; Darwish, Hala; Hamade, Eva; Habib, Aida... more authors ... less authors ( Elsevier , 2022 , Article)Traumatic Brain Injury (TBI) is one of the leading causes of death and disability worldwide. Aspirin (ASA) and clopidogrel (CLOP) are antiplatelet agents that inhibit platelet aggregation. They are implicated in worsening ... -
Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
Ghareghani, Majid; Ghanbari, Amir; Eid, Ali; Shaito, Abdullah; Mohamed, Wael; Mondello, Stefania; Zibara, Kazem... more authors ... less authors ( De Gruyter , 2021 , Article)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination. While the etiology of MS is still ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
Ola, El Atab; Ghantous, Crystal M.; El-Zein, Nabil; Farhat, Rima; Agouni, Abdelali; Korashy, Hesham M.; Djouhri, Laiche; Kamareddine, Layla; Zibara, Kazem; Zeidan, Asad... more authors ... less authors ( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ... -
Lipid-lowering therapies for atherosclerosis: Statins, fibrates, ezetimibe and pcsk9 monoclonal antibodies
Ali, A.H.; Younis, Nour; Abdallah, Rola; Shaer, Farah; Dakroub, Ali; Ayoub, Mohammed Akli; Iratni, Rabah; Yassine, Hadi Mohamad; Zibara, Kazem; Orekhov, Alexander; El-Yazbi, Ahmed Fawzy; Eid, Ali H.... more authors ... less authors ( Bentham Science Publishers , 2021 , Article Review)Cardiovascular disease (CVD) remains the primary cause of global morbidity and mortality. CVD includes various life-threatening conditions such as myocardial infarction, stroke and peripheral arterial diseases. In this ... -
Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications
Mallah, Khalil; Zibara, Kazem; Kerbaj, Coline; Eid, Ali; Khoshman, Nour; Ousseily, Zahraa; Kobeissy, Abir; Cardon, Tristan; Cizkova, Dasa; Kobeissy, Firas; Fournier, Isabelle; Salzet, Michel... more authors ... less authors ( Wiley , 2023 , Article Review)Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?
Reslan, Mohammad Amine; Issa, Hawraa; Al-Haj, Nadine; Ibeh, Stanley; Yehya, Yara; Hassan, Houssein Hajj; Kobeissy, Firas; Eid, Ali H.; Zibara, Kazem; Shaito, Abdullah; Mohamed, Wael; Yamashita, Toshihide... more authors ... less authors ( Springer Singapore , 2022 , Book chapter)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury?
Al-Haj, Nadine; Issa, Hawraa; El Zein, Ola; Ibeh, Stanley; Reslan, Mohammad Amine; Yehya, Yara; Kobeissy, Firas; Zibara, Kazem; Eid, Ali H.; Shaito, Abdullah; Mohamed, Wael; Yamashita, Toshihide... more authors ... less authors ( Springer Singapore , 2022 , Book chapter)Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ... -
Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction
Safiedeen, Zainab; Rodríguez-Gómez, Isabel; Vergori, Luisa; Soleti, Raffaella; Vaithilingam, Dayannath; Douma, Imene; Agouni, Abdelali; Leiber, Denis; Dubois, Séverine; Simard, Gilles; Zibara, Kazem; Andriantsitohaina, Ramaroson; Martínez, M. Carmen... more authors ... less authors ( Mary Ann Liebert, Inc. , 2017 , Article)Aims: Circulating microparticles (MPs) from metabolic syndrome patients and those generated from apoptotic T-cells induce endothelial dysfunction; however, the molecular and cellular mechanism(s) underlying in the effects ... -
Transforming growth factor-β1 inhibits interleukin-1β-induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells
Dhaouadi, Nedra; Nehme, Ali; Faour, Wissam H.; Feugier, Patrick; Cerutti, Catherine; Kacem, Kamel; Eid, Ali H.; Li, Jacques-Yuan; Zibara, Kazem... more authors ... less authors ( John Wiley and Sons Inc , 2021 , Article)Objective and design This study investigated the opposite mechanisms by which IL-1β and TGF-β1 modulated the inflammatory and migratory phenotypes in cultured human intimal vascular smooth muscle cells vSMCs. Materials ... -
Western and ketogenic diets in neurological disorders: can you tell the difference?
Habashy, Karl John; Ahmad, Fatima; Ibeh, Stanley; Mantash, Sarah; Kobeissy, Fatima; Issa, Hawraa; Habis, Ralph; Tfaily, Ali; Nabha, Sanaa; Harati, Hayat; Reslan, Mohammad Amine; Yehya, Yara; Barsa, Chloe; Shaito, Abdullah; Zibara, Kazem; El-Yazbi, Ahmed F; Kobeissy, Firas H... more authors ... less authors ( International Life Sciences Institute , 2022 , Article)The prevalence of obesity tripled worldwide between 1975 and 2016, and it is projected that half of the US population will be overweight by 2030. The obesity pandemic is attributed, in part, to the increasing consumption ... -
Western diet aggravates neuronal insult in post-traumatic brain injury: Proposed pathways for interplay
Abdullah, Shaito; Hasan, Hiba; Habashy, Karl John; Fakih, Walaa; Abdelhady, Samar; Ahmad, Fatima; Zibara, Kazem; Eid, Ali H.; El-Yazbi, Ahmed F.; Kobeissy, Firas H.... more authors ... less authors ( Elsevier , 2020 , Article Review)Traumatic brain injury (TBI) is a global health burden and a major cause of disability and mortality. An early cascade of physical and structural damaging events starts immediately post-TBI. This primary injury event ... -
XPC multifaceted roles beyond DNA damage repair: p53-dependent and p53-independent functions of XPC in cell fate decisions
Abir, Zebian; El-Dor, Maya; Shaito, Abdullah; Mazurier, Frédéric; Rezvani, Hamid Reza; Zibara, Kazem... more authors ... less authors ( Elsevier , 2022 , Article)Xeroderma pigmentosum group C protein (XPC) acts as a DNA damage recognition factor for bulky adducts and as an initiator of global genome nucleotide excision repair (GG-NER). Novel insights have shown that the role of XPC ...