Browsing by Author "Shalaby, Raed"
Now showing items 1-3 of 3
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Computer-Aided Design and Synthesis of N-aryl and Heteroarylpiperazine Derivatives as Dual Serotonergic Antagonists for Autism Treatment
Shalaby, Raed; Ghoneim, Ola; Khalil, Ashraf ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Background and Objective: Autism Spectrum Disorders (ASD) are characterized by abnormalities in social interaction and communication skills, in addition to stereotypic behaviors and restricted activities and interests. ... -
Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors
Hammuda, Arwa; Shalaby, Raed; Rovida, Stefano; Edmondson, Dale E.; Binda, Claudi; Khalil, Ashraf... more authors ... less authors ( Elsevier Masson SAS , 2016 , Article)A novel series of substituted chalcones were designed and synthesized to be evaluated as selective human MAO-B inhibitors. A combination of either methylsulfonyl or trifluoromethyl substituents on the aromatic ketone moiety ... -
SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
Shalaby, Raed; Petzer, Jacobus P.; Petzer, Anél; Ashraf, Usman M.; Atari, Ealla; Alasmari, Fawaz; Kumarasamy, Sivarajan; Sari, Youssef; Khalil, Ashraf... more authors ... less authors ( Taylor and Francis Ltd. , 2019 , Article)The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. ...