تصفح حسب المؤلف "Korashy, Hesham M."
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6-Formylindolo(3,2-b)carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation
Dhulkifle, Hevna; Sayed, Tahseen S.; Abunada, Hanan H.; Abulola, Sara M.; Alhoshani, Ali; Korashy, Hesham M.; Maayah, Zaid H.... more authors ... less authors ( American Chemical Society (ACS) , 2023 , Article)Patients with sepsis are at a high risk of morbidity and mortality due to multiple organ injuries caused by pathological inflammation. Although sepsis is accompanied by multiple organ injuries, acute renal injury is a ... -
Analysis of fatalities involving amphetamine in Jazan, Saudi Arabia
Ibraheem M., Attafi; Tumayhi, Murad M.; Banji, David; Albeishy, Mohammed Y.; Khardali, Ibrahim A.; Korashy, Hesham M.... more authors ... less authors ( Elsevier , 2021 , Article)Amphetamine use is associated with high tendence of homicidal or suicidal deaths and fatalities making amphetamine a persistent area of concern. This study analyzed fatalities associated with amphetamine use in Jazan city, ... -
Aryl Hydrocarbon Receptor Promotes Cell Growth, Stemness Like Characteristics, and Metastasis in Human Ovarian Cancer via Activation of PI3K/Akt, β-Catenin, and Epithelial to Mesenchymal Transition Pathways
Therachiyil, Lubna; Krishnankutty, Roopesh; Ahmad, Fareed; Mateo, Jericha M.; Uddin, Shahab; Korashy, Hesham M.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Ovarian cancer (OC) ranks first in cancer-related deaths out of all female reproductive malignancies with high-pitched tumor relapse and chemoresistance. Several reports correlate cancer occurrences with exposure to ... -
BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells.
Alhoshani, Ali; Alatawi, Fahad O; Al-Anazi, Fawaz E; Attafi, Ibraheem M; Zeidan, Asad; Agouni, Abdelali; El Gamal, Heba M; Shamoon, Licia S; Khalaf, Sarah; Korashy, Hesham M... more authors ... less authors ( Dove Medical Press , 2020 , Article)Venetoclax (VCX) is a selective BCL-2 inhibitor approved for the treatment of leukemia and lymphoma. However, the mechanisms of anti-cancer effect of VCX either as a monotherapy or in combination with other chemotherapeutic ... -
Cathine and cathinone disposition kinetics and neurotransmitter profile in several organs of rats exposed to a single dose of Catha edulis (Vahl) Forssk. ex Endl. extract
Alamir, Ahmad M.; Jeraiby, Mohammed A.; Korashy, Hesham M.; Shaheen, Emad Sayed; Attafi, Mohammad A.; Oraiby, Magbool E.; Hakami, Ahmed M.; Albeishy, Mohammed Y.; Khardali, Ibrahim A.; Juraybi, Ismail A.; Alobaida, Abeer A.; Attafi, Ibraheem M.... more authors ... less authors ( Walter de Gruyter , 2023 , Article)Catha edulis (Vahl) Forssk. ex Endl. (Khat) is a stimulant plant that contains cathine and cathinone, which its abuses induce euphoria, alertness, and motor activity. Since the toxicokinetics of these substances remain ... -
Correction to: Lead nitrate induces inflammation and apoptosis in rat lungs through the activation of NF‑κB and AhR signaling pathways (Environmental Science and Pollution Research, (2022), 29, 43, (64959-64970), 10.1007/s11356-022-19980-8)
Attafi, Ibraheem M.; Bakheet, Saleh A.; Ahmad, Sheikh F.; Belali, Osamah M.; Alanazi, Fawaz E.; Aljarboa, Suliman A.; AL‑Alallah, Ibrahim A.; Korashy, Hesham M.... more authors ... less authors ( Springer , 2022 , Article)The sizing of images Figs. 3 and 4 is modified in the original published proof. The Original article has been corrected. -
Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy
Abdullah, Al-Dhfyan; Alaiya, Ayodele; Al-Mohanna, Falah; Attwa, Mohamed W; AlAsmari, Abdullah F; Bakheet, Saleh A; Korashy, Hesham M.... more authors ... less authors ( Elsevier , 2022 , Article)IntroductionActivating the aryl hydrocarbon receptor upon exposure to environmental pollutants promotes development of breast cancer stem cell (CSCs). BCL-2 family proteins protect cancer cells from the apoptotic effects ... -
EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
Alhoshani, Ali; Alanazi, Fawaz E; Alotaibi, Moureq R; Attwa, Mohamed W; Kadi, Adnan A; Aldhfyan, Abdullah; Akhtar, Sabah; Hourani, Shireen; Agouni, Abdelali; Zeidan, Asad; Korashy, Hesham M... more authors ... less authors ( American Chemical Society , 2020 , Article)Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ... -
Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival.
Osman, Aisha; El-Gamal, Heba; Pasha, Mazhar; Zeidan, Asad; Korashy, Hesham M; Abdelsalam, Shahenda S; Hasan, Maram; Benameur, Tarek; Agouni, Abdelali... more authors ... less authors ( Frontiers Media , 2020 , Article)Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly ... -
Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes.
Maamoun, Hatem; Abdelsalam, Shahenda S; Zeidan, Asad; Korashy, Hesham M; Agouni, Abdelali ( MDPI , 2019 , Article)Physical inactivity and sedentary lifestyle contribute to the widespread epidemic of obesity among both adults and children leading to rising cases of diabetes. Cardiovascular disease complications associated with obesity ... -
Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway
Sabah, Akhtar; Hourani, Shireen; Therachiyil, Lubna; Al-Dhfyan, Abdullah; Agouni, Abdelali; Zeidan, Asad; Uddin, Shahab; Korashy, Hesham M.... more authors ... less authors ( Elsevier , 2020 , Article)Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that has been proposed as a strong sustainer and promoter of tumorigenesis and ... -
Experimental and theoretical investigations of the effect of bis-phenylurea-based aliphatic amine derivative as an efficient green corrosion inhibitor for carbon steel in HCl solution
Mohanad, Shkoor; Jalab, Rem; Khaled, Mazen; Shawkat, Tahseen S.; Korashy, Hesham M.; Saad, Mohamed; Su, Haw-Lih; Bani-Yaseen, Abdulilah Dawoud... more authors ... less authors ( Elsevier , 2023 , Article)A novel bis-phenylurea-based aliphatic amine (BPUA) was prepared via a facile synthetic route, and evaluated as a potential green organic corrosion inhibitor for carbon steel in 1.0 M HCl solutions. NMR spectroscopy ... -
In vivo and in vitro studies evaluating the chemopreventive effect of metformin on the aryl hydrocarbon receptor-mediated breast carcinogenesis
Ali, Alhoshani; Alotaibi, Moureq; As Sobeai, Homood M.; Alharbi, Naif; Alhazzani, Khalid; Al-Dhfyan, Abdullah; Alanazi, Fawaz E.; Korashy, Hesham M.... more authors ... less authors ( Elsevier , 2021 , Article)Metformin (MET) is a clinically used anti-hyperglycemic agent that shows activities against chemically-induced animal models of cancer. A study from our laboratory showed that MET protectes against 7, 12-dimethylbenz[a]anthracene ... -
Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder
Dhulkifle, Hevna; Agouni, Abdelali; Zeidan, Asaad; Al-Kuwari, Mohammed Saif; Parray, Aijaz; Tolefat, Mohamed; Korashy, Hesham M.... more authors ... less authors ( MDPI , 2021 , Article Review)Autism spectrum disorder (ASD) is an umbrella term that includes many different disorders that affect the development, communication, and behavior of an individual. Prevalence of ASD has risen exponentially in the past ... -
Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development
Sayed, Tahseen S.; Maayah, Zaid H.; Zeidan, Heba A.; Agouni, Abdelali; Korashy, Hesham M. ( BioMed Central Ltd , 2022 , Article Review)The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of research have been carried out to understand the role of AhR as ... -
Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction
Osman, Aisha; Benameur, Tarek; Korashy, Hesham M.; Zeidan, Asad; Agouni, Abdelali ( MDPI , 2020 , Article)Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
Ola, El Atab; Ghantous, Crystal M.; El-Zein, Nabil; Farhat, Rima; Agouni, Abdelali; Korashy, Hesham M.; Djouhri, Laiche; Kamareddine, Layla; Zibara, Kazem; Zeidan, Asad... more authors ... less authors ( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ... -
Lead Nitrate Induces Inflammation and Apoptosis in Rat Lungs Through the Activation of NF-κB and AhR Signaling Pathways
Attafi, Ibraheem M.; Bakheet, Saleh A.; Ahmad, Sheikh F.; Belali, Osamah M.; Alanazi, Fawaz E.; Aljarboa, Suliman A.; AL-Alallah, Ibrahim A.; Korashy, Hesham M.... more authors ... less authors ( Springer , 2022 , Article)Lead (Pb) is one of the most frequent hazardous air contaminants, where the lungs are particularly vulnerable to its toxicity. However, the Pb distribution and its impact on lung inflammation/apoptosis and particularly the ... -
Letter to the Editor Response
Abdul, Salam; Kamran, Sadat; Bibi, Rubina; Korashy, Hesham M.; Parray, Aijaz; Mannai, Adbulla Al; Ansari, Abdulrahman Al; Kanikicharla, Krishna Kumar; Gashi, Arta Zogaj; Shuaib, Ashfaq... more authors ... less authors ( Elsevier , 2020 , Other)To the Editor We thank Dr. Luis Rafael Moscote-Salazar and Dr. Amit Agrawal for their interest in our recently published article in the Journal.1 The authors do not raise any concerns about the scientific facts and the ... -
Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
Fawaz E., Alanazi; As Sobeai, Homood M.; Alhazzani, Khalid; Al-Dhfyan, Abdullah; Alshammari, Musaad A; Alotaibi, Moureq; Al-hosaini, Khaled; Korashy, Hesham M.; Alhoshani, Ali... more authors ... less authors ( Elsevier , 2021 , Article)Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) ...