تصفح حسب المؤلف "Raza, Afsheen"
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Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
Akbar, Shayista; Raza, Afsheen; Mohsin, Reyad; Kanbour, Aladdin; Qadri, Shahnaz; Parray, Aijaz; Zar Gul, Abdul Rehman; Philip, Anite; Vijayakumar, Suma; Merhi, Maysaloun; Hydrose, Shereena; Inchakalody, Varghese Philipose; Al-Abdulla, Rajaa; Abualainin, Wafa; Sirriya, Shaza Abu; Al-Bozom, Issam; Uddin, Shahab; Khan, Omar Muhammad; Mohamed Ibrahim, Mohamed Izham; Al Homsi, Ussama; Dermime, Said... more authors ... less authors ( Frontiers Media S.A. , 2023 , Article)Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% of the patients still ... -
Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
Fernandes, Queenie; Inchakalody, Varghese Philipose; Merhi, Maysaloun; Mestiri, Sarra; Taib, Nassiba; Moustafa Abo El-Ella, Dina; Bedhiafi, Takwa; Raza, Afsheen; Al-Zaidan, Lobna; Mohsen, Mona O.; Yousuf Al-Nesf, Mariam Ali; Hssain, Ali Ait; Yassine, Hadi Mohamad; Bachmann, Martin F.; Uddin, Shahab; Dermime, Said... more authors ... less authors ( Taylor and Francis , 2022 , Article)The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing ... -
Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance.
Maacha, Selma; Bhat, Ajaz A; Jimenez, Lizandra; Raza, Afsheen; Haris, Mohammad; Uddin, Shahab; Grivel, Jean-Charles... more authors ... less authors ( Springer Verlag , 2019 , Article)The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of the tumor ... -
Non-Invasive Biomarkers for Early Lung Cancer Detection
Saman, Harman; Raza, Afsheen; Patil, Kalyani; Uddin, Shahab; Crnogorac-Jurcevic, Tatjana ( MDPI , 2022 , Article Review)Worldwide, lung cancer (LC) is the most common cause of cancer death, and any delay in the detection of new and relapsed disease serves as a major factor for a significant proportion of LC morbidity and mortality. Though ... -
Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study
Mestiri, Sarra; Merhi, Maysaloun; Inchakalody, Varghese P.; Taib, Nassiba; Smatti, Maria K.; Ahmad, Fareed; Raza, Afsheen; Ali, Fatma H.; Hydrose, Shereena; Fernandes, Queenie; Ansari, Abdul W.; Sahir, Fairooz; Al-Zaidan, Lobna; Jalis, Munir; Ghoul, Mokhtar; Allahverdi, Niloofar; Al Homsi, Mohammed U.; Uddin, Shahab; Jeremijenko, Andrew Martin; Nimir, Mai; Abu-Raddad, Laith J.; Abid, Fatma Ben; Zaqout, Ahmed; Alfheid, Sameer R.; Saqr, Hassan Mohamed Hassan; Omrani, Ali S.; Hssain, Ali Ait; Al Maslamani, Muna; Yassine, Hadi M.; Dermime, Said... more authors ... less authors ( Frontiers Media , 2023 , Article)Introduction: The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Methods: ... -
The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer.
Siveen, Kodappully S; Raza, Afsheen; Ahmed, Eiman I; Khan, Abdul Q; Prabhu, Kirti S; Kuttikrishnan, Shilpa; Mateo, Jericha M; Zayed, Hatem; Rasul, Kakil; Azizi, Fouad; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( MDPI , 2019 , Article)Colorectal cancer (CRC) is one of the most common cancers worldwide, with high morbidity and mortality rates. A number of factors including modulation of the tumor microenvironment, high metastatic capability, and resistance ... -
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.
Akhtar, Sabah; Achkar, Iman W; Siveen, Kodappully S; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Khan, Abdul Q; Ahmed, Eiman I; Sahir, Fairooz; Jerobin, Jayakumar; Raza, Afsheen; Merhi, Maysaloun; Elsabah, Hesham M; Taha, Ruba; Omri, Halima El; Zayed, Hatem; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Frontiers Media , 2019 , Article)Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a ... -
Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
Taib, Nassiba; Merhi, Maysaloun; Inchakalody, Varghese; Mestiri, Sarra; Hydrose, Shereena; Makni-Maalej, Karama; Raza, Afsheen; Sahir, Fairooz; Azizi, Fouad; Nizamuddin, Parveen B.; Fernandes, Queenie; Yoosuf, Zeenath Safira K. M.; Almoghrabi, Salam; Al-Zaidan, Lobna; Shablak, Alaaeldin; Uddin, Shahab; Maccalli, Cristina; Al Homsi, Mohammed Ussama; Dermime, Said... more authors ... less authors ( BioMed Central Ltd , 2023 , Article)Background: The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and ...